Automatic high-pressure on-line filtering device for separation equipment and use method of automatic high-pressure on-line filtering device

Abstract

The invention discloses an automatic high-pressure on-line filtering device for separation equipment. The automatic high-pressure on-line filtering device comprises a power module, a pre-tightening module, a filtering column core and a filtering shell, wherein the filtering column core is a storage container of samples to be filtered; a filtering plate is arranged at the bottom of the filtering column core; the filtering shell is arranged at the bottom of the filtering column core and is used for fixing the filtering column core; a liquid outlet is formed in the bottom of the filtering shell;the pre-tightening module is arranged below the filtering shell; the filtering column core is placed outside the filtering shell; the filtering column core is fixed by the pre-tightening module; meanwhile, tight connection of the filtering column core with the filtering shell can be maintained; the power module is arranged above the filtering column core; and the power module is pressed into the filtering column core to compact the samples tightly. The device is capable of tightly compressing the samples automatically, is integrated into a whole liquid path system, and is capable of enduring high pressure of the whole system and ensuring that phenomena of liquid leakage and splashing can be avoided when a liquid flows through the whole device. Before a sample is fed into a chromatographiccolumn, real-time on-line filtering is firstly implemented on the sample, and thus the chromatographic column can be prevented from being contaminated.

Description

technical field [0001] The invention relates to a filter device, in particular to an automatic high-pressure online filter device for separation equipment, which is used to assist high-pressure separation equipment to complete sample pretreatment. Furthermore, the invention also relates to methods of using the device. Background technique [0002] Using high-pressure preparative HPLC (High Performance Liquid Chromatography) to separate the product, it is necessary to use high-pressure mixed flow items (petroleum ether, ethanol) to flush the solid sample into the chromatographic column, but because there are impurities in the solid sample, the sample directly enters the chromatographic column. It will pollute the chromatographic column, seriously reduce the service life of the chromatographic column, and the price of the chromatographic column is high, so the sample needs to be filtered before the sample enters the chromatographic column. [0003] Technical means: The existi...

AI Technical Summary

Problems solved by technology

[0005] 1. Manual operation wastes manpower time

[0006] 2. The existing method cannot realize online real-time filtering

[0007] 3. The syringe and filter head are disposable and cannot be reused, which is a waste of cost

[0008] 4. Unable to withstand 10-15mpa high pressure

[0009] 5. Use scenarios that do not meet automation

The device is not corrosion-resistant and cannot be applied to the filtration of chemical reagents, and cannot withstand high pressure. At the same time, the filter cylinder cannot be replaced, which limits the diversity of filtered samples and cannot solve the problem of cross-contamination of different samples.

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