Transdermal precision drug-delivery device based on microneedle-type ionophoresis device and preparation method thereof

Abstract

The invention belongs to the technical field of medical drug delivery devices, and specifically discloses a transdermal precision drug-delivery device based on a microneedle-type ionophoresis device.The transdermal precision drug-delivery device comprises a composite microneedle, a DC power source and a skin electrode sheet which are sequentially connected by wires, and the composite microneedlecomprises a microneedle patch and a controllableg drug-loading substrate. The microneedle patch is a hydrogel microneedle with a grid gap formed by crosslinking polyethylene glycol-crosslinked polyvinyl methyl ether-maleic acid. The drug-loading substrate comprises a photo-cured polyethylene glycol diacrylate (PEGDA) and a composite hydrogel coated with insulin, and a back surface of the compositehydrogel is provided with a microneedle electrode sheet. The drug delivery device efficiently realizes macro-molecule transdermal administration such as insulin, and greatly improves the transdermaldiffusion rate of insulin by ion electrophoresis. The device can achieve more precise and controllable administration by changing the voltage, current and time of ion electrophoresis, realizes intelligent release and termination of insulin, and more accurately regulate blood sugar.

Description

technical field [0001] The invention belongs to the technical field of medical drug delivery devices, in particular to a transdermal precise drug delivery device based on a microneedle ionophoretic device and a preparation method thereof. Background technique [0002] In the prior art, diabetes is a metabolic disease characterized by the failure of the blood sugar level regulation mechanism, and it is the third chronic non-communicable disease that endangers human health after cardiovascular and cerebrovascular diseases and tumors. The latest analysis report published by the International Diabetes Federation shows that the number of adults with diabetes (20-79 years old) has increased from 151 million in 2000 to 425 million in 2017, an increase of nearly 2 times, and more than 5.1 million people die directly or indirectly from diabetes every year. Diabetes, and it is increasing every year. It is estimated that by 2045, there will be more than 600 million diabetic patients, ...

AI Technical Summary

Problems solved by technology

However, frequent injections and infusions will bring patients pain and risk of infection caused by bacteria, viruses, etc., inflammation and related complications

In addition, insulin cannot enter the body through the gastrointestinal tract after oral administration, because the gastrointestinal tract is highly acidic and rich in a variety of microbial components and digestive enzymes that can attack and degrade proteins, resulting in the loss of macromolecular protein hormones. Drugs are easily broken down

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