A photoelectric integrated stretchable flexible nerve electrode and its preparation method

Abstract

The invention provides a photoelectric integrated stretchable flexible neural electrode and a preparation method. The flexible neural electrode comprises a first elastic substrate, a photostimulationelectrode, a second elastic substrate and a recording electrode, and the photostimulation electrode and the recording electrode are both in snakelike curved wire arrangement structures. The lower surface of the photostimulation electrode is provided with a first silicon dioxide layer, and the photostimulation electrode is bonded to the surface of the first elastic substrate by strong chemical bonds generated in condensation reaction of the first silicon dioxide layer and the first elastic substrate. The upper surface of the photostimulation electrode is provided with the second elastic substrate, the lower surface of the recording electrode is provided with a second silicon dioxide layer, and the recording electrode is bonded to the surface of the second elastic substrate through strong chemical bonds generated in condensation reaction of the second silicon dioxide layer and the second elastic substrate, so that the recording electrode and the photostimulation electrode are integratedstructurally. The flexible neutral electrode is available for long-term implantation, high in flexibility and capable of bearing deformation influences of brain tissue expansion and shrinkage and thelike.

Description

technical field [0001] The invention belongs to the nerve microelectrode in the technical field of biomedical engineering, and in particular relates to a photoelectric integrated stretchable flexible nerve electrode and a preparation method thereof. Background technique [0002] With the rapid progress and development of brain-computer interface and neuroscience, an in-depth understanding of brain function and diseases has become one of the frontiers of research around the world. With the help of flexible electronic science and MEMS micro-nano processing capabilities, flexible neural microelectrodes are increasingly used to accurately collect high-density, high-information EEG signals, providing a basis for research on neural circuit functions, diagnosis of brain lesions, and neural decoding. provide new tools. [0003] Since the emergence of optogenetics, which allows people to precisely stimulate or inhibit a specific type of neuron, it has become an indispensable tool fo...

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Problems solved by technology

However, due to the weak adhesion of polyimide and PDMS itself, it is difficult to ensure that the device does not delaminate during use, and also only has a single EEG recording function, not combined with light stimulation.

[0007] In summary, there is currently no report of a stretchable brain-computer interface flexible electrode that integrates precise light stimulation and cortical electrical signal acquisition. The reasons include complex processing technology and high requirements for device integration, so it is urgent to develop a flexible electrode. It can be implanted for a long time, is highly flexible, can withstand deformation effects such as expansion and contraction, and integrates flexible nerve electrodes with precise light stimulation functions to meet the needs of various brain science and neuroscience research tools.

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