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Blood amitriptyline drug concentration monitoring kit and detection method thereof

A technology of amitriptyline and a kit, which is applied in the field of amitriptyline therapeutic drug monitoring kits in blood, can solve the problems of high technical requirements for experimenters, inaccurate qualitative and quantitative analysis, and long analysis time, so as to reduce errors and The effect of personnel operation error, simple and fast detection process, and reduced experimental cost

Inactive Publication Date: 2019-10-22
苏州艾迪迈医疗科技有限公司
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  • Abstract
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  • Claims
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Problems solved by technology

Previous methods have problems such as complicated pre-treatment, inaccurate qualitative and quantitative results, high cost, long analysis time, or high technical requirements for experimenters.

Method used

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  • Blood amitriptyline drug concentration monitoring kit and detection method thereof
  • Blood amitriptyline drug concentration monitoring kit and detection method thereof
  • Blood amitriptyline drug concentration monitoring kit and detection method thereof

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Embodiment Construction

[0035] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with illustrations and specific embodiments.

[0036] One, the preparation of amitriptyline therapeutic drug monitoring kit:

[0037] Standard curve reagent: Amitriptyline is prepared into a series of concentrations with animal serum containing 2% stabilizer and 2% plasticizer, respectively 0.035mg / L, 0.090mg / L, 0.135mg / L, 0.225mg / L , 0.340mg / L, 0.455mg / L, 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle.

[0038] Quality Control Reagent: Amitriptyline is formulated with animal serum containing 2% stabilizer and 2% plasticizer to three concentrations of high, medium and low, respectively 0.060mg / L, 0.150mg / L, 0.340mg / L, Dispense 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the ass...

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Abstract

The invention relates to the field of medical detection and in particular to a blood amitriptyline therapeutic drug monitoring kit developed based on multi-dimensional online solid-phase extraction liquid chromatography analytical technology, more specifically to a method for accurately and quantitatively detecting amitriptyline drug concentration in blood by online solid-phase extraction and multi-dimensional liquid chromatography analytical technology. The kit includes a calibration reagent, a quality control reagent, a processing liquid, an extract liquid, a washing liquid, and an eluent. The therapeutic drug monitoring kit of the invention only needs to centrifuge a blood sample, achieves low repeated detection variability, high accuracy and stability, and low detection cost, has various methodological indicators that satisfy the requirement for monitoring the blood amitriptyline therapeutic drugs, and is easy to generalize.

Description

technical field [0001] The invention relates to the field of medical testing, in particular to a kit for monitoring amitriptyline therapeutic drug in blood developed based on multi-dimensional online solid phase extraction liquid chromatography analysis technology, more specifically, it adopts online solid phase extraction and multidimensional liquid A method for accurate and quantitative monitoring of amitriptyline drug concentration in blood by phase chromatography analysis technology. Background technique [0002] Amitriptyline is the most commonly used clinical tricyclic antidepressant, its pharmacological effect is to block the reuptake of norepinephrine and 5-hydroxytryptamine in nerve endings, thereby increasing the concentration of transmitters in the synaptic cleft and promoting synaptic stimulation. Play an antidepressant effect by triggering the transmission function. The effective blood concentration of amitriptyline is 0.080-0.200mg / L, and when the blood concen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/16G01N30/34G01N30/86
CPCG01N30/06G01N30/16G01N30/34G01N30/8631
Inventor 何伶秀石功名
Owner 苏州艾迪迈医疗科技有限公司
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