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Blood lamotrigine drug concentration monitoring kit and detection method thereof

A lamotrigine and kit technology, which is applied in the field of lamotrigine therapeutic drug monitoring kits in blood, can solve the problems of high technical requirements for experimenters, inaccurate qualitative and quantitative, complicated pretreatment, etc. The effect of personnel operation error, simple and fast detection process, and reduced experimental cost

Inactive Publication Date: 2019-10-22
苏州艾迪迈医疗科技有限公司
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  • Claims
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Problems solved by technology

Previous methods have problems such as complicated pre-treatment, inaccurate qualitative and quantitative results, high cost, long analysis time, or high technical requirements for experimenters.

Method used

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  • Blood lamotrigine drug concentration monitoring kit and detection method thereof
  • Blood lamotrigine drug concentration monitoring kit and detection method thereof
  • Blood lamotrigine drug concentration monitoring kit and detection method thereof

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Embodiment Construction

[0035] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with illustrations and specific embodiments.

[0036] One, the preparation of lamotrigine therapeutic drug monitoring kit:

[0037] Standard curve reagent: where lamotrigine is prepared into a series of concentrations with animal serum containing 2% stabilizer and 2% plasticizer, respectively 0.5mg / L, 1.0mg / L, 5.0mg / L, 10.0mg / L , 15.0mg / L, 20.0mg / L, 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle.

[0038] Quality control reagent: Lamotrigine is formulated with animal serum containing 2% stabilizer and 2% plasticizer to three concentrations of high, medium and low, respectively 1.0mg / L, 10.0mg / L, 16.0mg / L, Dispense 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle.

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Abstract

The invention relates to the field of medical detection and in particular to a blood lamotrigine therapeutic drug monitoring kit developed based on multi-dimensional online solid-phase extraction liquid chromatography analytical technology, more specifically to a method for accurately and quantitatively detecting lamotrigine drug concentration in blood by online solid-phase extraction and multi-dimensional liquid chromatography analytical technology. The kit includes a calibration reagent, a quality control reagent, a processing liquid, an extract liquid, a washing liquid, and an eluent. The therapeutic drug monitoring kit of the invention only needs to centrifuge a blood sample, achieves low repeated detection variability, high accuracy and stability, and low detection cost, has various methodological indicators that satisfy the requirement for monitoring the blood lamotrigine therapeutic drugs, and is easy to generalize.

Description

technical field [0001] The invention relates to the field of medical detection, in particular to a kit for monitoring lamotrigine therapeutic drug in blood developed based on multidimensional on-line solid-phase extraction liquid chromatography analysis technology, more specifically, it adopts on-line solid-phase A method for accurate and quantitative monitoring of lamotrigine drug concentration in blood by phase chromatography analysis technology. Background technique [0002] Lamotrigine is a closed voltage application-dependent sodium ion hyperchannel blocker. It produces an application-compliant block of sustained repetitive discharges and inhibits the pathological release of glutamate (an amino acid that plays a key role in the formation of epileptic seizures) as well as the bursting of glutamate-evoked action potentials . The effective plasma concentration of lamotrigine is 3.0-14.0mg / L, and when the plasma concentration>14.0mg / L, the toxic and side effects will b...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/16G01N30/34G01N30/86
CPCG01N30/06G01N30/16G01N30/34G01N30/8631
Inventor 石功名何伶秀
Owner 苏州艾迪迈医疗科技有限公司
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