High-resolution time-of-flight mass spectrometer quasi-in-situ reaction monitoring system

Abstract

The invention discloses a high-resolution time-of-flight mass spectrometer quasi-in-situ reaction monitoring system, which comprises a high-resolution time-of-flight mass spectrometer, an in-situ reaction device and an automatic flow division dilution transmission device; The in-situ reaction device comprises a reactor, two injection pumps and a heating magnetic stirrer, wherein the two injectionpumps are connected to the reactor through PEEK tubes. The automatic flow division dilution transmission device includes a constant flow pump, a stop valve, a six-way valve and a flow divider, whereinthe stop valve, the constant flow pump and the flow divider are connected with the six-way valve through the PEEK tubes. Reaction liquid to be measured in an in-situ reactor is quickly divided, diluted and transferred to the mass spectrometer under the condition of no contact with air to complete the quasi-in-situ reaction monitoring of the chemical reaction, thereby thoroughly solving the problem that it is difficult to detect chemical intermediates and unstable intermediates under a conventional chemical detection method of the high-resolution time-of-flight mass spectrometer and expandingthe function the high-resolution time-of-flight mass spectrometer in the aspect of reaction mechanism study.

Description

technical field [0001] The invention relates to a quasi-in-situ reaction monitoring system of a high-resolution time-of-flight mass spectrometer, in particular to a quasi-in-situ reaction monitoring system capable of capturing chemical reaction intermediates and unstable intermediate products. Functional expansion of detection of reaction intermediates and unstable intermediates. Background technique [0002] The high-resolution time-of-flight mass spectrometer is mainly used to determine the precise relative molecular mass of the compound, and then the molecular formula of the compound can be deduced by combining the abundance ratio information. The types of compounds that can be analyzed by this instrument are very large, and it has become an important tool in synthetic chemistry, coordination chemistry, metal-organic, biological inorganic, natural products, drug development, pharmacokinetics, combinatorial chemistry and biomacromolecule (polypeptide, protein) chemistry, e...

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Problems solved by technology

[0004] Aiming at the problem that chemical reaction intermediates and unstable intermediate products are not easy to capture under the conventional detection mode of high-resolution time-of-flight mass spectrometers, the present invention designs a set of high-resolution time-of-flight mass spectrometers on the basis of existing high-resolution time-of-flight mass spectrometers quasi in situ reaction monitoring system

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