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Photoelectric microneedle, as well as preparation method and application thereof

A photoelectric effect and photoelectric technology, applied in microneedling, phototherapy, needles, etc., can solve the problems of unclean lesion removal, large skin damage area, easy recurrence, etc., achieving good application prospects, efficient killing, and broad development space. Effect

Active Publication Date: 2019-10-18
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the problems of unclean lesion resection, large skin damage area and easy recurrence caused by the existing methods for killing body surface cancer, and to provide a method that can quickly and efficiently kill body surface cancer cells, A method that completely removes the lesion without damaging the skin and leaving no scars

Method used

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  • Photoelectric microneedle, as well as preparation method and application thereof
  • Photoelectric microneedle, as well as preparation method and application thereof
  • Photoelectric microneedle, as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0063] Embodiment 1 Preparation of photoelectric microneedles

[0064] A method for preparing a photoelectric microneedle, specifically comprising the following steps:

[0065] S1. Mix zinc oxide and graphite phase carbon nitride at a mass ratio of 0.21:1 to obtain nanoparticles with photoelectric effect, and prepare nanoparticles with a concentration of 250 μg / mL;

[0066] S2. Mix the nanoparticles obtained in step S1 with hyaluronic acid in a ratio of 1:1, and stir to obtain a mixture;

[0067] S3. The mixture obtained in step S2 is injected into the microneedle array mold under the condition of a pressure of 5Mpa, and heated to 80°C at a speed of 5°C / min, and the heating time is 8h;

[0068] S4. After cooling and forming, the photoelectric microneedles are taken out from the microneedle array mold.

[0069] In step S1, the preparation method of nanoparticles with a concentration of 250 μg / mL is as follows: put 1 mg of nanoparticles into DMEM high-glucose medium containing...

Embodiment 2

[0072] Embodiment 2 Preparation of photoelectric microneedles

[0073] A method for preparing a photoelectric microneedle, specifically comprising the following steps:

[0074] S1. Mix zinc oxide and graphite phase carbon nitride at a mass ratio of 0.08:1 to obtain nanoparticles with photoelectric effect, and prepare nanoparticles with a concentration of 250 μg / mL;

[0075] S2. Mix the nanoparticles obtained in step S1 with polylactic acid in a ratio of 3:5, and stir to obtain a mixture;

[0076] S3. inject the mixture obtained in step S2 into the microneedle array mold under the condition of a pressure of 1Mpa, and heat to 60°C at a speed of 2°C / min for a heating time of 4h;

[0077] S4. After cooling and forming, the photoelectric microneedles are taken out from the microneedle array mold.

[0078] In step S1, the preparation method of nanoparticles with a concentration of 250 μg / mL is the same as that in Example 1.

[0079] The diameter of the photoelectric microneedle c...

Embodiment 3

[0080] Example 3 Preparation of photoelectric microneedles

[0081] A method for preparing a photoelectric microneedle, specifically comprising the following steps:

[0082] S1. Mix zinc oxide and graphite phase carbon nitride at a mass ratio of 0.42:1 to obtain nanoparticles with photoelectric effect, and prepare nanoparticles with a concentration of 250 μg / mL;

[0083] S2. Mix the nanoparticles obtained in step S1 with hyaluronic acid in a ratio of 8:5, and stir to obtain a mixture;

[0084] S3. The mixture obtained in step S2 is injected into the microneedle array mold under the condition of a pressure of 10Mpa, and heated to 90°C at a speed of 7°C / min for a heating time of 12h;

[0085] S4. After cooling and forming, the photoelectric microneedles are taken out from the microneedle array mold.

[0086] In step S1, the preparation method of nanoparticles with a concentration of 250 μg / mL is the same as that in Example 1.

[0087] The diameter of the photoelectric microne...

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Abstract

The invention discloses a photoelectric microneedle, as well as a preparation method and application thereof. The invention first provides the method for preparing the photoelectric microneedle whichis prepared from nano-particles with a photoelectric effect and a biodegradable raw material in a mass ratio of (3-8):5. The method has simple operation, low cost and good repeatability. The photoelectric microneedle prepared by the method has sufficient puncture performance, can puncture the stratum corneum and reach the corium layer, can be used for delivering the nano-particles with the photoelectric effect to tumor location, generating a photoelectric signal under lighting and quickly and efficiently killing cancer cells on the body surface, does not hurt skin or leave a scar. The photoelectric microneedle can be biodegraded in the body, and the degraded product does not have toxic or side effect, so that the photoelectric microneedle has excellent application prospect and wide development space in preparation of medicines for treating body surface cancers.

Description

technical field [0001] The invention belongs to the field of photoelectric materials, and more specifically relates to a photoelectric microneedle and its preparation method and application. Background technique [0002] Body surface tumors refer to tumors growing on the body surface, which can be divided into benign tumors and malignant tumors. Common benign tumors on the body surface include: melanoma, hemangioma, neurofibroma, wart and xanthoma, etc. Common body surface tumors Surface malignant tumors, also known as surface cancers, include: skin cancer, melanoma, and skin sarcoma. For benign tumors on the surface that only invade the epidermis and dermis, appropriate non-surgical therapy can be selected for treatment. Once the tumor reaches below the dermis, surgical therapy is appropriate; for surface cancer, surgical therapy is the main treatment. [0003] With the influence of factors such as population aging, changes in living patterns, and environmental pollution, ...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023A61M2037/0053A61M2037/0061A61N5/062A61N2005/0612
Inventor 易新袁志山王成勇凌新生
Owner GUANGDONG UNIV OF TECH
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