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A kind of injection filling microsphere preparation and preparation method thereof

A technology of microspheres and microspheres, which is applied in the fields of medical cosmetology and biomedicine, can solve the problems of permanent injection fillers such as long-term foreign body reaction, aseptic inflammation, and short maintenance time, so as to achieve good filling effect, prevent degradation, The effect of moderate degradation time

Active Publication Date: 2021-10-22
王月玲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many kinds of injectable beauty products on the market, but there are still many deficiencies in the existing products. For example, most of the degradable injectable fillers only play the role of physical filling, the maintenance time is short, and repeated injections are required; permanent injectable fillers exist Long-term foreign body reaction can easily lead to aseptic inflammation and cannot be removed

Method used

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  • A kind of injection filling microsphere preparation and preparation method thereof
  • A kind of injection filling microsphere preparation and preparation method thereof
  • A kind of injection filling microsphere preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The preparation of embodiment 1 microspheres and gel

[0057] To 20L mass concentration of 0.2% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 6L mass concentration of 2% polylactide (intrinsic viscosity is 0.4dl / g) dichloromethane solution, stir for 3 hours, The stirring speed is 350rpm, and the mixture in the reactor is released. Suction filtration, vacuum drying, ready for filling.

[0058] Add 30 g of mannitol and 30 g of hydroxymethyl methylcellulose sodium into 1 L of water for injection, stir at 30° C. at a stirring speed of 350 rpm, and form a gel after fully dissolving.

Embodiment 2

[0059] The preparation of embodiment 2 microspheres and gel

[0060] To 10L mass concentration of 0.5% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add mass concentration of 10L5% polylactide (intrinsic viscosity is 1.0dl / g) chloroform solution, stir for 8 hours, stirring speed 500rpm , release the mixture in the reactor. Suction filtration, vacuum drying, ready for filling.

[0061] Add 50 g of glucose and 30 g of hydroxypropyl methylcellulose sodium into 1 L of water for injection, stir at 20° C. at a stirring speed of 350 rpm, and form a gel after fully dissolving.

Embodiment 3

[0062] The preparation of embodiment 3 microspheres and gel

[0063] To 20L mass concentration is 1.0% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 15L mass concentration as 10% polylactide (intrinsic viscosity is 2.0dl / g) ethyl acetate solution, stir 15 hours, The stirring speed is 650rpm, and the mixture in the reaction kettle is released; it is filtered, vacuum-dried, and prepared for filling.

[0064] Add 26 g of glycerin and 28 g of sodium carboxymethylcellulose into 1 L of water for injection, stir at 50° C. at a stirring speed of 350 rpm, and form a gel after fully dissolving.

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Abstract

The invention relates to an injection-filled microsphere preparation and a preparation method thereof, belonging to the technical fields of medical cosmetology and biomedicine. The injection filling microsphere preparation provided by the present invention comprises a microsphere agent and a gel, the microsphere agent is a polyglycolide microsphere with a particle diameter of 5-200 μm; the gel agent is an osmotic pressure regulator and a gel A gel made of matrix, wherein the osmotic pressure regulator is one or more of mannitol, glycerin, glucose or sodium chloride; the gel matrix is ​​carboxymethylcellulose, sodium hydroxypropylmethylcellulose Or one or more of sodium methylcellulose. The injection-filled microsphere preparation provided by the invention can be used in the field of plastic surgery. The product has uniform spherical shape, controllable particle size specification, good biocompatibility, moderate degradation time, and degradation products can be completely absorbed by the human body. No residue in the body is an injectable microsphere preparation for filling and modifying anti-aging, skin beautification, and facial rejuvenation.

Description

technical field [0001] The invention belongs to the technical fields of medical cosmetology and biomedicine, and in particular relates to an injection-filled microsphere preparation and a preparation method thereof. Background technique [0002] It has become a common phenomenon to correct soft tissue defects and repair aging and wrinkled skin through plastic surgery technology, so as to maintain the perfect and youthful facial shape. Among various plastic surgery techniques, injection beauty technology accounts for the largest proportion, accounting for about 40% of the entire beauty market. Injection beauty technology is a beauty technology that partially modifies the human body through injection to achieve exquisite local shape and harmonious overall shape. This technology has the characteristics of zero recovery, quick effect and high safety, and is the first choice for beauty needs. [0003] At present, there are many kinds of injectable beauty products on the market,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61L27/58
CPCA61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61L27/58A61L2300/622A61L2400/06C08L67/04C08L29/04C08L1/284C08L1/286C08L1/28
Inventor 王月玲
Owner 王月玲
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