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Application of chicoric acid in preparation of medicament for treating obesity or complications thereof

A technology of cichoric acid and obesity, applied in the field of biomedicine, can solve the problems that the effect has not been reported, and achieve the effect of reducing renal tubular damage, expanding the scope of application, and improving kidney function

Active Publication Date: 2019-10-15
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its role in improving renal tubular damage in obesity has not been reported

Method used

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  • Application of chicoric acid in preparation of medicament for treating obesity or complications thereof
  • Application of chicoric acid in preparation of medicament for treating obesity or complications thereof
  • Application of chicoric acid in preparation of medicament for treating obesity or complications thereof

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Experimental program
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Embodiment Construction

[0021] The present invention will be described in detail below in conjunction with specific embodiments.

[0022] 1. Animal experiments

[0023] 1. Grouping and handling of experimental animals

[0024] Male C57BL / 6 mice were acclimated to the environment for one week, normal control mice were fed a normal diet, and the model group was fed a high-fat diet (Research Diets D12492, 60kcal%). After 12 weeks, the mice were divided into groups. ①The original normal control group was still the normal group, and the mice in the model group were randomly divided into ②model blank group, treatment group: ③Chichoric acid low-dose group (15mg / kg / ) and ④Chicory acid high dose group (30mg / kg / d). The normal group and the model blank group were intragastrically administered with 0.5% CMC-Na, while the treatment group were intragastrically administered with low and high doses of cichoric acid. Body weight was measured weekly.

[0025] 2. Sample collection and processing

[0026] Urine was...

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Abstract

The invention discloses application of chicoric acid in preparation of a medicament or a health product for treating obesity or complications thereof. The invention expands the application range of the chicoric acid, and the chicoric acid can effectively regulate the body weight and the blood fat level of a high-fat model mouse, improve the kidney function and reduce renal tubular injury.

Description

technical field [0001] The invention relates to a new application of cichoric acid, in particular, a new application in the preparation of obese renal tubule injury medicine, which belongs to the field of biomedicine. Background technique [0002] In recent decades, with the improvement of living standards, great changes have taken place in people's dietary structure and lifestyle. Long-term excessive intake of high-calorie foods and poor lifestyles due to lack of exercise cause fat accumulation in the body and lead to obesity. Weight gain, blood triglyceride (Triglyceride, TG), total cholesterol (Total cholesterol, TC), low-density lipoprotein cholesterol (LDL cholesterol, LDL-C) levels increased and high-density lipoprotein cholesterol (HDLcholesterol, HDL- C) Reduced levels are the main feature of obesity. Obesity patients are at high risk of end-stage renal disease [Futatsugi, K., Tokuyama, H., Shibata, S., et al. (2016).]. Lipid accumulation in the kidney can induce...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P3/04A61P3/06A61P13/12
CPCA61K31/216A61P3/04A61P3/06A61P13/12
Inventor 丁晓琴简暾昱吕寒陈剑任冰如童贝马丽孟秀花
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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