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Acyl-sn-glycerol-3-phosphate compound and application thereof

A technology of phosphoric acid and compound, which is applied in the directions of edible phospholipid composition, application, compound of elements of Group 5/15 of the periodic table, etc., to achieve the effects of high safety, high market value and wide range of sources

Inactive Publication Date: 2019-09-27
江苏中酶生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the central nervous system appetite suppressant lorcaserin and Qsymia have become the first weight-loss drugs approved by the FDA in 13 years, there are still safety uncertainties in the brain center and cardiovascular system

Method used

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  • Acyl-sn-glycerol-3-phosphate compound and application thereof
  • Acyl-sn-glycerol-3-phosphate compound and application thereof
  • Acyl-sn-glycerol-3-phosphate compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A 1,2-acyl-sn-glycerol-3-phosphate derived from soybean, its structural formula is:

[0032]

[0033] 1,2-acyl-sn-glycero-3-phosphate is composed of a glycerol backbone, in which the hydroxyl group 1 is replaced by a saturated fatty acid chain, the hydroxyl group 2 is replaced by an unsaturated fatty acid chain, and the hydroxyl group 3 is replaced by a phosphate group replace.

[0034] The preparation method of 1,2-acyl-sn-glycero-3-phosphate is:

[0035] (1) Weigh 100 parts by weight of 1,2-acyl-sn-glycero-3-phosphocholine (content is 99.5%) derived from soybean, 400 parts by weight of purified water and 1 part by weight of phospholipase D In the reaction vessel, stir evenly, and stir and react at 45°C for 24 hours;

[0036] (2) After the reaction finishes, collect the insolubles by centrifugation, add 1000 parts by weight of purified water to the reaction solution, collect the insolubles by centrifugation, then add 1000 parts by weight of absolute ethanol and pu...

Embodiment 2

[0039] Example 2: Application of the 1,2 acyl-sn-glycerol-3-phosphate prepared in Example 1 to control the body weight of mice

[0040] (1) Experimental sample: 1,2-acyl-sn-glycero-3-phosphate (content 99%, W / W) prepared in Example 1.

[0041] (2) Experimental objects: 24 male mice, 24 newborn male mice were placed in separate mouse cages in a room, and the room temperature, humidity and light were controlled (21-23°C, 12-12 hours black and white light cycle), fed them basic diet and unlimited drinking water. After 14 weeks, they were divided into three groups according to body weight, namely experimental group 1, experimental group 2 and control group; experimental group 1: 8 mice, respectively fed with 0.2% high-fat diet of acyl-sn-glycerol-3-phosphate compounds (HFD+0.2% 1,2-acyl-sn-glycero-3-phosphate); experimental group 2: 8 mice, fed with High-fat diet (HFD+0.2% 1,2-acyl-sn-glycero-3-phosphate) containing 1.0% acyl-sn-glycero-3-phosphate compound by weight; control gro...

Embodiment 3

[0045] Example 3: Application of 1,2-acyl-sn-glycerol-3-phosphate prepared in Example 1 to control blood lipid levels in mice

[0046] (1) Experimental method: get the fresh blood of three groups altogether 24 mice in the 35th week in embodiment 2, total cholesterol (CHDL), triglyceride (TG), high-density lipoprotein cholesterol (HDL) in serum -C), the levels of low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (APA), apolipoprotein B (APB) and lipoprotein a (LP(a)) were detected, and the detection results are shown in Table 2 shown.

[0047] Table 2

[0048]

[0049] (2) Experimental conclusion: as can be seen from Table 2, compared with the matched group, high-density lipoprotein cholesterol (HDL-C) level significantly increases in the mouse serum in embodiment 1 and embodiment 2, lipoprotein a (LP( a)) The experimental results show that the level is significantly reduced, and 1,2-acyl-sn-glycerol-3-phosphate can better control the blood lipid level of mice....

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Abstract

The invention discloses an acyl-sn-glycerol-3-phosphate compound and application thereof. The structural formula of the acyl-sn-glycerol-3-phosphate compound is shown in the description, wherein R1 and R2 are independently selected from H and a fatty acid chain acyl residue, and R3 is a phosphate group; the application refers to application of the acyl-sn-glycerol-3-phosphate compound in controlling the body weight and the blood lipid level. The acyl-sn-glycerol-phosphate compound has a significant weight reducing effect, has wide sources which can be natural sources such as animals and plants, has high safety and has potential high market value.

Description

technical field [0001] The invention relates to the field of acyl-sn-glycerol-3-phosphate compounds, in particular to an acyl-sn-glycerol-3-phosphate compound and applications thereof. Background technique [0002] With the awakening of Chinese residents' health awareness, exercise is gradually becoming one of the main lifestyles of residents. The size of the sports crowd continues to increase, and they are divided into general sports and fitness groups and professional athletes according to the purpose of sports. [0003] The purpose of exercise for general exercise and fitness groups is mainly to lose weight and shape, and control obesity. Obesity refers to a physical condition in which excess body fat accumulates and negatively affects health, which may lead to shortened life span and various health problems. The standard of obesity is often measured by body mass index (BMI), which is the square of weight (kg) divided by height (m). Westerners think that a BMI greater ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10A61K31/661A61P3/04A61P3/06A23L33/12
CPCA23V2002/00A23L33/12A61P3/04A61P3/06C07F9/103A23V2200/332A23V2250/186
Inventor 严明陈圣章志林魏淼陈晶晶
Owner 江苏中酶生物科技有限公司
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