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Preparation method and application of polypeptide compound and latent HIV (human immunodeficiency virus) activation drug

A peptide compound and drug technology, applied in the application field of marine microbial drugs, can solve the problems of unsatisfactory clinical research results, low activity, high drug toxicity, etc., and achieve the goal of increasing the growth rate of bacteria, high culture efficiency and low difficulty Effect

Active Publication Date: 2019-09-20
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these latent activators often have disadvantages such as low activity and high drug toxicity, and their clinical research results are not satisfactory.

Method used

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  • Preparation method and application of polypeptide compound and latent HIV (human immunodeficiency virus) activation drug
  • Preparation method and application of polypeptide compound and latent HIV (human immunodeficiency virus) activation drug
  • Preparation method and application of polypeptide compound and latent HIV (human immunodeficiency virus) activation drug

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Embodiment Construction

[0026] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be described in detail below in conjunction with the examples. It should be understood that the embodiments described in this specification are only for explaining the present invention, not for limiting the present invention, and the parameters and proportions of the embodiments can be selected according to local conditions and have no substantial influence on the results.

[0027] Preparation of polypeptide compounds

[0028] 1) Strain activation: Take out the seed-preserving culture dish of Aspergillus versicolor from the refrigerator at 4°C, culture it in a constant temperature incubator at 28°C for a period of time, pick the hyphae of Aspergillus versicolor and inoculate it into a new PDA medium on, cultured for 3 to 5 days.

[0029] 2) Preparation of seed liquid: take out the culture dish of Aspergillus versicolor strains after success...

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Abstract

The invention discloses application of a polypeptide compound ad its salt in the preparation of latent HIV (human immunodeficiency virus) activation drugs. A structural formula of the polypeptide compound is shown in the description. It is discovered through studies that the polypeptide compound has latent HIV activation activity and can activate latent HIV effectively, while general activation of T cells is not widely triggered; the polypeptide with high activity is applicable to the preparation of latent HIV activation drugs. The invention also provides a preparation method of the polypeptide compound; marine fungi having rich origins are cultured directly to obtain the polypeptide compound; existing natural resources are utilized fully; compared with organic direct synthesis, the preparation method herein adopting fermenting culture has less difficulty and is suitable for large-scale industrial cultivation.

Description

technical field [0001] The invention belongs to the application field of marine microbial drugs, and in particular relates to a preparation method of a polypeptide compound and its application and a drug for latent activation of HIV. Background technique [0002] As of 2016, an estimated 36.7 million people worldwide were still living with HIV. In the same year, approximately 1.8 million people were newly infected with HIV, and 1 million people died from diseases related to HIV infection. Although highly active antiretroviral therapy (HAART) has a good effect on the control of HIV replication and transmission: HAART therapy can maximally inhibit the replication of HIV virus and make the copy number of HIV ~1 in the patient's plasma below the detection level, However, since HAART cannot completely eliminate HIV that has the ability to replicate but is in a latent state, patients often need to receive HAART treatment for life to ensure viral suppression. [0003] "Shock kill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61P31/18C12P21/02C12R1/66
CPCA61K38/06A61P31/18C07K5/0819
Inventor 杨献文谢春兰夏金梅樊少强罗钦
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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