Preparation method of vancomycin-modified copper sulphide nanoparticles

Abstract

The invention belongs to the field of nanotechnology, and particularly relates to a preparation method of vancomycin-modified copper sulfide nanoparticles. Vancomycin is adopted as a reducing agent and a wrapping agent, and a one-step method is used for preparation, the copper sulfide nanoparticles are synthesized, and meanwhile surface decoration of the vancomycin is achieved; the synthesis step is synthesized, the reaction yield is improved, and obtained vancomycin-modified copper sulfide nanoparticles have high purity and good stability and biocompatibility, and can be used for photothermal therapy of vancomycin resistant bacteria.

Description

technical field [0001] The invention belongs to the field of nanotechnology, in particular to a preparation method of vancomycin-modified copper sulfide nanoparticles. Background technique [0002] Vancomycin (Van for short) is a class of glycopeptide antibiotics used to prevent and treat Gram-positive pathogenic bacteria infections. Because vancomycin has strong sterilizing activity and is not easy to make bacteria resistant, it is only allowed to be used when other antibiotics cannot treat bacterial infections, so it is called "the last line of defense of antibiotics". However, with the overuse of vancomycin in clinical practice, reports of vancomycin-resistant Enterococci (VRE), a "superbug", have appeared in succession all over the world. Due to the lack of effective preventive measures and regulatory mechanisms, VRE drug-resistant strains spread rapidly all over the world, and the number is increasing year by year. At present, the incidence of VRE infection in my coun...

AI Technical Summary

Problems solved by technology

In order to accurately locate the treatment site, the copper sulfide nanoparticles obtained by sodium citrate reduction need to undergo subsequent targeted molecular modification, and the modification process has problems such as cumbersome process and low efficiency.

At the same time, organic reagents containing biotoxicity are often used in the synthesis process, which greatly reduces the stability and biocompatibility of copper sulfide nanoparticles.

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