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Use of brown algae-derived glucuronic acid-rich low-sulfated heteroglycan in the preparation of medicaments for the treatment of type 2 diabetes

A technology for glucuronic acid and type 2 diabetes, which is applied in the directions of medical raw materials derived from algae, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of severe diabetes control status and other issues

Active Publication Date: 2019-09-10
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are a variety of drugs for hypoglycemia, the current situation of diabetes control is still very severe

Method used

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  • Use of brown algae-derived glucuronic acid-rich low-sulfated heteroglycan in the preparation of medicaments for the treatment of type 2 diabetes
  • Use of brown algae-derived glucuronic acid-rich low-sulfated heteroglycan in the preparation of medicaments for the treatment of type 2 diabetes
  • Use of brown algae-derived glucuronic acid-rich low-sulfated heteroglycan in the preparation of medicaments for the treatment of type 2 diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Preparation of low sulfated heteroglycans

[0036] The detailed preparation method and structural characteristics of low-sulfated heteropolysaccharides have been disclosed in the previous patent (Application of low-sulfated heteropolysaccharides rich in glucuronic acid derived from brown algae in the preparation of drugs and health products for the treatment of Parkinson's disease, application publication number : CN 103539863 A), the used number of the present invention is consistent with the previous patent.

[0037] Specifically, laminarin components involved in the examples of the present invention-F1, F2, F3, Sargassum polysaccharide components-S1, S2, Sargassum polysaccharide SP, sea millet polysaccharide, Naozhou Sargassum polysaccharide, half The preparation method of the polysaccharide of Sargassum phyllosum and Sargassum whole margin is as follows.

[0038] Preparation of Laminarin Components-F1, F2, F3

[0039] (1) Remove silt from 5 kg of kel...

Embodiment 2

[0053] Example 2: Low sulfated heteroglycans can promote glucose consumption in HepG2 cells

[0054] HepG2 is a human liver cancer cell line, which grows rapidly and has stable properties. It is a commonly used cell line for studying liver protection. Promote glucose metabolism in peripheral tissues and improve the sensitivity of liver cells to insulin. Metformin and the polysaccharide of Example 1 were used for drug treatment for 24 hours, and glucose oxidase method was used to measure the change of glucose in the culture solution. The results (Table 1) show that low sulfated heteropolysaccharides promote glucose consumption more than fucoidan sulfate.

[0055] Table 1. Effect of Polysaccharide Fractions (1 mg / ml and 0.1 mg / ml) on Promoting Glucose Consumption Rate

[0056]

Embodiment 3

[0057] Example 3: Low sulfated heteroglycans can enhance insulin secretion of pancreatic beta cells

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Abstract

The present invention provides the use of brown algae-derived glucuronic acid-rich low-sulfated heteroglycan in the preparation of medicaments or health products for the treatment and / or prevention oftype 2 diabetes. The low-sulfated heteroglycan has the following characteristics: the monosaccharide component mainly comprises fucose and glucuronic acid, and further comprises one or more of mannose, glucose, rhamnose, galactose, xylose, guluronic acid and mannuronic acid; wherein the content of the hydrolyzed sulfate group is 5 to 28 percent, the content of the fucose is 3 to 28 percent and the content of the uronic acid is 5 to 30 percent. The heteroglycan has stronger effect on promoting glucose consumption in HepG2 cells than fucoidan sulfate fraction, and it has obvious effect on enhancing insulin secretion in islet beta cells.

Description

[0001] (1) Technical field [0002] The invention relates to the application of a class of low-sulfated heteroglycans rich in glucuronic acid derived from marine brown algae in the preparation of medicines or health products for treating and / or preventing type 2 diabetes. [0003] (2) Background technology [0004] Diabetes is one of the diseases that seriously affect human life and health today. The WHO report pointed out that in 2014, there were about 422 million adults with diabetes in the world, and the prevalence rate reached 8.5%; and the prevalence rate is increasing year by year. Although there are a variety of drugs for hypoglycemia, the current situation of diabetes control is still very severe. 63% of patients with type 2 diabetes still cannot receive effective treatment, and the level of glycosylated hemoglobin (HBA1c) in the body is greater than the standard level of 7% proposed by the American Diabetes Association. Therefore, it is necessary to further reveal th...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/737A61P3/10A61P5/50
CPCA61K31/737A61K36/03A61P3/10A61P5/50C08B37/006
Inventor 金维华钟卫鸿何新月王鸿张文静
Owner ZHEJIANG UNIV OF TECH
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