Method for preparing biphenyl derivative by using microchannel continuous flow reactor

Abstract

The invention belongs to the field of organic fine synthesis, and relates to a method for preparing a biphenyl derivative by using a microchannel continuous flow reactor. The method comprises the steps: adopting the microchannel continuous flow reactor, feeding a grignard reagent, halogenated benzene, a solvent and a catalyst in a slurry feeding mode, and performing a reaction at 50-200 DEG C anda pressure of 0.1-2.0 MPa so as to obtain the biphenyl derivative. The preparation process of the biphenyl derivative has the characteristic of continuous feeding, the reaction space is a channel witha depth of 100 [mu]m-10 mm, and the reaction temperature and pressure can be set flexibly when the reaction is compared with conventional batch reactions, the reaction time is shortened from severalhours to several tens of seconds, a high reaction yield, few side reactions and a good mass transfer effect are achieved, and the safety problem brought by fierce heat release of reactions and other problems are solved; and the method can be applied to large-scale production of biphenyl derivatives, and provides a green economical and environment-friendly industrial preparation route for the compounds.

Description

technical field [0001] The invention relates to the field of synthesis of fine organic compounds, in particular to a method for preparing biphenyl derivatives using a microchannel continuous flow reactor. Background technique [0002] Biphenyl compounds play an important role in modern materials and chemical industry. For example, they can be used as monomers to prepare high-performance polyimides and liquid crystal polymer materials. They can be used as important ligands for asymmetric catalysis, and as intermediates for drug molecules. Metal-catalyzed carbon-carbon bond coupling is the most important way to prepare biphenyl compounds. So far, many coupling methods have been developed for carbon-carbon bond structures: Suzuki coupling, Kumada coupling, Ullmann coupling, Nigishi coupling, Stille coupling, Hiyama coupling, etc. However, this type of reaction usually requires the preparation of expensive metal-organic compound precursors for coupling, the use of noble metal ...

AI Technical Summary

Problems solved by technology

Low heat transfer efficiency will lead to high local temperature, and uneven mass transfer will lead to high local concentration of the material, which will easily lead to rapid temperature rise and lead to out-of-control reaction, eventually causing dangers such as overflow and explosion.

And as the reaction proceeds, the concentration of the reaction substrate will gradually decrease, and the reaction will gradually slow down or even stop. Even if the reaction time is increased, it is difficult to ensure the complete conversion of the reactant

On the one hand, it causes a large amount of unreacted format reagents to be wasted; on the other hand, due to the high activity of format reagents, post-processing such as quenching has high risks

Therefore, it is difficult to meet the requirements of safety, stability and high efficiency of the reaction at the same time based on the batch tank process developed by the existing technology.

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