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Aminomethylbenzoic acid sodium chloride injection and preparation method thereof

A technology of aminotoluic acid sodium chloride and aminotoluic acid, applied in the field of injection, can solve problems such as lack of application of aminotoluic acid

Inactive Publication Date: 2019-09-10
辽宁海神联盛制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, the effect of general chronic bleeding is more significant, and there is no hemostatic effect on massive wound bleeding. However, there are relatively few studies on puerarin injection at home and abroad, and the application of p-aminomethylbenzoic acid is lacking.

Method used

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  • Aminomethylbenzoic acid sodium chloride injection and preparation method thereof
  • Aminomethylbenzoic acid sodium chloride injection and preparation method thereof
  • Aminomethylbenzoic acid sodium chloride injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0016] An aminotoluic acid sodium chloride injection, the raw material of this injection consists of: aminotoluic acid 5kg, sodium chloride 26kg, activated carbon 1.1kg, water for injection added to 3000000ml;

[0017] The preparation method of described aminomethylbenzoic acid sodium chloride injection is:

[0018] (1) Weighing: select raw materials according to the formula;

[0019] (2) Concentrated formulation: take an appropriate amount of water for injection, heat and stir the prescribed amount of sodium chloride to dissolve, add 0.1-0.3% (w / v) activated carbon (for injection), and boil for 15 minutes;

[0020] (3) Filtration: Cool the medicinal liquid prepared in step (2) to 55±5° C., decarbonize and filter it into the dilution tank;

[0021] (3) Dilute formulation: dilute the prescribed amount of aminomethylbenzoic acid with water for injection, add it to the sodium chloride solution in the dilute formulation tank, stir well to dissolve, and then add water for injectio...

Embodiment 2

[0026] A kind of aminotoluic acid sodium chloride injection, the raw material of this injection consists of: aminotoluic acid 7kg, sodium chloride 28kg, activated carbon 1.3kg, water for injection added to 3000000ml;

[0027] The preparation method of described aminomethylbenzoic acid sodium chloride injection is:

[0028] (1) Weighing: select raw materials according to the formula;

[0029] (2) Concentrated formulation: take an appropriate amount of water for injection, heat and stir the prescribed amount of sodium chloride to dissolve, add 0.1-0.3% (w / v) activated carbon (for injection), and boil for 15 minutes;

[0030] (3) Filtration: Cool the medicinal liquid prepared in step (2) to 55±5° C., decarbonize and filter it into the dilution tank;

[0031] (3) Dilute formulation: dilute the prescribed amount of aminomethylbenzoic acid with water for injection, add it to the sodium chloride solution in the dilute formulation tank, stir well to dissolve, and then add water for i...

Embodiment 3

[0036] A kind of aminotoluic acid sodium chloride injection, the raw material of this injection consists of: aminotoluic acid 6kg, sodium chloride 27kg, activated carbon 1.2kg, water for injection added to 3000000ml;

[0037] The preparation method of described aminomethylbenzoic acid sodium chloride injection is:

[0038] (1) Weighing: select raw materials according to the formula;

[0039] (2) Concentrated formulation: take an appropriate amount of water for injection, heat and stir the prescribed amount of sodium chloride to dissolve, add 0.1-0.3% (w / v) activated carbon (for injection), and boil for 15 minutes;

[0040] (3) Filtration: Cool the medicinal liquid prepared in step (2) to 55±5° C., decarbonize and filter it into the dilution tank;

[0041] (3) Dilute formulation: dilute the prescribed amount of aminomethylbenzoic acid with water for injection, add it to the sodium chloride solution in the dilute formulation tank, stir well to dissolve, and then add water for i...

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Abstract

The invention discloses an aminomethylbenzoic acid sodium chloride injection and a preparation method thereof. Raw materials of the injection are composed of: 5-7 kg of aminomethylbenzoic acid, 26-28kg of sodium chloride, 1.1-1.3 kg of activated carbon, and water for injection and the total being 3000000 ml. The invention provides the stable and safe aminomethylbenzoic acid sodium chloride injection, solves the technical problem that aminomethylbenzoic acid sodium chloride is stable and sensitive to light, and provides the safe aminomethylbenzoic acid sodium chloride injection for a clinicalapplication.

Description

technical field [0001] The invention relates to an injection, in particular to an aminotoluic acid sodium chloride injection and a preparation method thereof. Background technique [0002] Aminomethylbenzoic acid, p-aminomethylbenzoic acid monohydrate. It is suitable for abnormal bleeding during operations on the lung, liver, pancreas, prostate, thyroid, adrenal gland, etc., obstetrics and gynecology and postpartum hemorrhage, tuberculosis hemoptysis, blood in sputum, hematuria, prostatic hypertrophy bleeding, upper gastrointestinal bleeding, aminomethylbenzoic acid is Anticoagulant drugs. There are various natural antagonists of plasmin (original) in the blood circulation, such as anti-plasmin and so on. Under normal circumstances, the activity of anti-fibrinolytic substances in the blood is many times higher than that of fibrinolytic substances, so fibrinolytic bleeding will not occur. However, these antagonists cannot block the activation of activators (such as urokina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/02A61K31/195A61P7/04
CPCA61K9/0019A61K9/08A61K31/195A61K47/02A61P7/04
Inventor 曹建科李桂红徐凤娟
Owner 辽宁海神联盛制药有限公司
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