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Preparation method and applications of Codonopsis pilosula polysaccharide-iron complex

A technology of Codonopsis polysaccharide and complex, which is applied in the field of preparation of Codonopsis polysaccharide iron complex, can solve the problems of low absorption and utilization rate and many side effects, and achieve the effects of enhancing biological activity, high bioavailability and enhancing human immunity.

Active Publication Date: 2019-09-03
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The main purpose of the present invention is to propose a preparation method and application of Codonopsis polysaccharide iron complex, aiming to solve the defects of low absorption utilization rate and many side effects of existing iron supplement preparations

Method used

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  • Preparation method and applications of Codonopsis pilosula polysaccharide-iron complex
  • Preparation method and applications of Codonopsis pilosula polysaccharide-iron complex
  • Preparation method and applications of Codonopsis pilosula polysaccharide-iron complex

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preparation example Construction

[0035] In view of this, the present invention proposes a method for preparing Codonopsis polysaccharide-iron complex, which can prepare a Codonopsis polysaccharide-iron complex, which is easy to absorb and utilize, has a good iron supplement effect and does not cause gastrointestinal reactions . combine figure 1 A schematic flow diagram of an embodiment of the proposed preparation method of the Codonopsis polysaccharide-iron complex, the preparation method of the Codonopsis polysaccharide-iron complex comprises the following steps:

[0036] Step S10, adding citric acid into the aqueous solution of Codonopsis polysaccharide, stirring evenly to form a mixed solution.

[0037] In the technical solution of the present invention, Codonopsis polysaccharide is used as a ligand, citric acid is added to Codonopsis polysaccharide solution, and then reacted with ferric chloride to load iron ions on Codonopsis polysaccharide. Wherein, the amount of citric acid added will affect the comp...

Embodiment 1

[0059] Adding citric acid into the aqueous solution of Codonopsis polysaccharide, stirring evenly to form a mixed solution, wherein the mass ratio of citric acid to Codonopsis polysaccharide contained in the aqueous solution of Codonopsis polysaccharide is 3:1. Under stirring conditions, 2mol / L ferric chloride solution and 20% sodium hydroxide solution were added dropwise to the mixed solution to form a reaction solution, and the pH of the reaction solution was maintained at 9 by controlling the dropping rate. When the reddish-brown precipitate in the reaction solution no longer disappeared, stop the dropwise addition of the ferric chloride solution and the sodium hydroxide solution and place the reaction solution in a water bath at 60° C. for 1.5 h to obtain a mixture. The mixture was centrifuged at 8000r / min for 10min, and the supernatant was collected; the supernatant was alcohol-precipitated and left to stand for 22h, the precipitate was taken and washed with ethanol, and t...

Embodiment 2

[0061] Adding citric acid into the aqueous solution of Codonopsis polysaccharide, stirring evenly to form a mixed solution, wherein the mass ratio of citric acid to Codonopsis polysaccharide contained in the aqueous solution of Codonopsis polysaccharide is 3:1. Under stirring conditions, 1.8mol / L ferric chloride solution and 25% sodium hydroxide solution were added dropwise to the mixed solution to form a reaction solution, and the pH of the reaction solution was maintained at 8 by controlling the dropping rate. When the reddish-brown precipitate in the reaction solution no longer disappeared, the dropwise addition of the ferric chloride solution and the sodium hydroxide solution was stopped and the reaction solution was placed in a water bath at 80° C. for 2 hours to obtain a mixture. The mixture was centrifuged at 8000r / min for 11min, and the supernatant was collected; the supernatant was alcohol-precipitated and left to stand for 26h, the precipitate was taken and washed wit...

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Abstract

The invention discloses a preparation method and applications of a Codonopsis pilosula polysaccharide-iron complex, and relates to the technical field of macromolecule polysaccharides. The preparationmethod comprises: adding citric acid to a Codonopsis pilosula polysaccharide aqueous solution, and stirring uniformly to form a mixed solution; adding a ferric chloride solution and a sodium hydroxide solution to the mixed solution in a dropwise manner under a stirring condition, and carrying out a reaction to obtain a mixture; and carrying out separation purification treatment on the mixture toobtain the Codonopsis pilosula polysaccharide-iron complex. According to the present invention, the prepared Codonopsis pilosula polysaccharide-iron complex is easily absorbed and utilized by the body, has high bioavailability, cannot cause adverse effects on the gastrointestinal tract, can supplement the body with safe and non-toxic iron elements, and has good antitumor activity.

Description

technical field [0001] The invention relates to the technical field of polymer polysaccharides, in particular to a preparation method and application of Codonopsis polysaccharide-iron complex. Background technique [0002] Iron is an essential trace element in the human body and an important component of hemoglobin, myoglobin and various enzymes in human blood. When iron deficiency or iron utilization in the body is impaired, the synthesis of hemoglobin will be reduced, and the amount of hemoglobin in new red blood cells will be insufficient; severe iron deficiency will not only cause anemia, but also cause the lack of iron-containing enzymes in the body, resulting in obstacles to cellular respiration , affect the function of tissues and organs, clinically can cause dysfunction of gastrointestinal tract, circulation, nervous system and so on. Iron deficiency and iron deficiency anemia are the most common malnutrition in the world today, and they are also micronutrient defic...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P3/02A61P35/00A61P39/06A61P37/02
CPCA61P3/02A61P35/00A61P37/02A61P39/06C08B37/006
Inventor 袁帅张西锋鄢又玉李万芬
Owner WUHAN POLYTECHNIC UNIVERSITY
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