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Application of nicotinamide-containing mononucleotide formula in field of preparing anti-ageing nutritional health-care products or drugs

A single nucleotide and nicotinamide technology, which is applied in the field of compositions for the treatment of senile diseases, can solve the problems of functional degradation or damage of the patient's body, poor treatment effect, and decreased quality of life, so as to achieve no side effects and adverse reactions. , Enhance immunity, good anti-aging effect

Inactive Publication Date: 2019-08-23
创美全球有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current technical means to treat functional degenerative diseases caused by aging can only be treated symptomatically, that is, interventional therapy is started after the symptoms of the disease appear. Although this method has a certain effect, the patient's body function has already been degraded or damaged , the quality of life has declined significantly, and the treatment effect at this time is not very good
More importantly, the elderly often suffer from a variety of geriatric diseases, and the current technology has great limitations in treating a variety of geriatric diseases at the same time

Method used

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  • Application of nicotinamide-containing mononucleotide formula in field of preparing anti-ageing nutritional health-care products or drugs
  • Application of nicotinamide-containing mononucleotide formula in field of preparing anti-ageing nutritional health-care products or drugs
  • Application of nicotinamide-containing mononucleotide formula in field of preparing anti-ageing nutritional health-care products or drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. A composition with anti-aging effect and preparation method thereof:

[0020] Dissolve 60g of propylene glycol and 50g of polyethylene glycol in 1000g of high-purity water, then add 200g of nicotinamide mononucleotide, 15g of biotin, 50g of acai berry extract, 10g of grape seed extract, and 60g of blueberry extract, and stir evenly to make it After completely dissolving, it is sterilized by Co60-γ-ray radiation at a dose of 9kGy, and is recorded as an anti-aging solution for future use.

[0021] 2 cell culture

[0022] Control group cell culture: normal human fibroblast WI-38 strain was subcultured to 30 passages in DMEM medium (adding 10% fetal bovine serum and 100X penicillin-streptomycin), and inoculated with 2×10 4 ~5×10 4 The subcultured cells were cultured in a 35mm culture dish for 3 days, and treated with phosphate buffer solution (1.37mol / L NaCl, 27mmol / L KCl, 100 mmol / L NaCl 2 HPO 4 , 18mmol / L KH 2 PO 4 ) Wash the cells twice, fix the cells with 3.7% ...

Embodiment 2

[0027] 1. A composition with anti-aging effect and preparation method thereof:

[0028] Heat 60kg of propylene glycol and 50kg of polyethylene glycol to melt, mix well, add 100g of nicotinamide mononucleotide, 15kg of biotin, 50kg of acai berry extract, 10kg of grape seed extract, 60kg of blueberry extract, and pass through a homogenizer Afterwards, it is pressed into soft capsules, and the filling capacity is 1g / grain, as anti-aging capsules.

[0029] 2. Clinical Trial Methods

[0030] a. Select 208 inpatients or outpatients diagnosed with chronic gouty arthritis by general data, and randomly divide them into a treatment group and a control group; among them, there are 104 cases in the treatment group, 84 males and 20 females; 41 years old and under 41 years old 10 cases, 46 cases aged 42 to 51, 36 cases aged 52 to 61, and 12 cases aged over 61; the shortest course was 8 months, the longest was 23 years, and the average course was 4.0 years. The control group included 104 c...

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Abstract

The invention relates to a composition of nicotinamide-containing mononucleotide, biotin and Acai berry extracts and application thereof in the field of preparing anti-ageing nutritional health-care products or drugs. The anti-ageing composition and other excipients are together prepared into dosage forms such as particles, tablets, capsules and oral liquid for people to take. Accordingly, the three effective components are combined together, the synergistic effect is achieved, and by means of the reasonable proportion, the anti-ageing function is achieved. Meanwhile, symptoms such as Parkinsonism, Alzheimer's syndrome and cardiovascular and cerebrovascular diseases which are caused by ageing can be relieved, and the effects of increasing immunity and preventing and treating tumors are achieved.

Description

technical field [0001] The invention relates to the field of medical care, in particular to a composition for treating senile diseases. Background technique [0002] With the development of medicine and the progress of society, the life expectancy of human beings is getting longer and longer. At present, the main factors leading to the death of the elderly, such as cardiovascular diseases, have relatively effective treatments, so the mortality rate of the elderly has been greatly reduced. The overall result is that older people make up an increasing proportion of the population. [0003] There are more and more elderly people, but the quality of life of these people has not been improved accordingly, and some diseases caused by aging still plague the elderly. Taking Alzheimer's disease as an example, data show that the incidence rate of people over 65 years old is 4.8%, and the incidence rate of people over 85 years old has increased to 8%. Therefore, improving the health ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P9/00A61P25/16A61P25/28A61P35/00A61P37/04A61P39/00A61K31/4188A61K31/706
CPCA61K31/4188A61K31/706A61K36/45A61K36/48A61K36/704A61K36/87A61K36/889A61P9/00A61P25/16A61P25/28A61P35/00A61P37/04A61P39/00A61K2300/00
Inventor 梁沁晁慧晁慧萍
Owner 创美全球有限公司
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