Application of saussurea costus essential oil

A technology of cloudwood and essential oils, applied in the field of biomedicine, to achieve the effects of improving cognitive function, improving metabolic stability, and reducing toxicity

Inactive Publication Date: 2019-08-16
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Application of saussurea costus essential oil
  • Application of saussurea costus essential oil
  • Application of saussurea costus essential oil

Examples

Experimental program
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Effect test

preparation example Construction

[0040] The preparation method of the eucalyptus essential oil of the present invention comprises steam distillation extraction and carbon dioxide supercritical extraction.

[0041] The essential oil of the aloe wood according to the present invention is detected by a gas chromatography-mass spectrometry instrument, and the contained components are aplotaxene (>20%) and costol (>8%) by mass percentage. , dehydrocostuslactone (>6%), α-selinene (>5%), caryophyllene oxide (caryophyllene oxide) (>4%).

Embodiment 1

[0043] Take 100Kg of dried roots, stems, leaves or achenes of Aucklandia lappa Decne. (Saussurea lappa Clarke), pile them up for 2 days, crush them to 50 mesh coarse particles, soak the coarse particles in 8 mass times the pH value 5.0 hydrochloric acid aqueous solution, leaching overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain the essential oil of fenugreek.

Embodiment 2

[0045] Get 120Kg of dried roots, stems, leaves or achenes of Inula helenium L., pile them up for 2 days, grind them to 50 mesh coarse particles, soak the coarse particles in 8 mass times the amount of pH value of 5.0 hydrochloric acid aqueous solution, Leach overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain the woody essential oil.

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Abstract

The invention discloses application of saussurea costus essential oil. The application of the saussurea costus essential oil comprises application of the saussurea costus essential oil in preparationof a drug for treating or preventing brain function and disorder diseases thereof, and application of the saussurea costus essential oil in preparation of a health product for improving the brain function and disorder diseases thereof. According to the invention, the new application of the saussurea costus essential oil in drugs or large health products showing activity in the brain functions anddisorder diseases of experimental animals is discovered for the first time; and it discovers for the first time that the saussurea costus essential oil or the composition containing the saussurea costus essential oil or any of them can improve symptoms of animals with brain functions and disorder thereof such as Alzheimer's disease, depression and anxiety in an animal in-vivo model. Compared withexisting drugs for treating the brain functions and disorders thereof, the saussurea costus essential oil or any composition thereof has a mechanism of inhibiting synergistic effect of multiple molecules such as cholinesterase and regulating neurotransmitters on multiple targets, has good pharmacokinetic parameters, is easy to permeate a blood-brain barrier, and has the characteristics of toxicological safety, stable metabolism, longer half-life and / or smaller side effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of the essential oil of eucalyptus in the preparation of medicines or health products for treating and preventing brain function and its disorders. Background technique [0002] Cloud wood incense is the Compositae plant wood incense (Aucklandia lappa Decne.) (Saussurea lappa Clarke), native to India, Liang Dai imported from Guangzhou. At present, it is mainly cultivated in Yunnan, Sichuan, Guangxi and other places. The dried root of Yunmuxiang is an important traditional Chinese medicinal material, which has been recorded in successive dynasties of herbal medicines. "Pharmacopoeia of the People's Republic of China" over the years has also recorded that the dried root of basilica has the effects of promoting qi and relieving pain, invigorating the spleen and eliminating food, and is used to treat chest and flank, abdominal distension and pain, heavy diarrhea ...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61P25/00A61P25/24A61P25/22A61P25/20A61P25/28A61P25/08A61P25/18A61P9/10A61P25/14A61P25/16A61K8/92A61Q19/00A61Q19/10A61L9/013C11B9/02
CPCA61K36/285A61P25/00A61P25/24A61P25/22A61P25/20A61P25/28A61P25/08A61P25/18A61P9/10A61P25/14A61P25/16A61K8/922A61Q19/00A61Q19/10A61L9/013C11B9/02C11B9/027C11B9/025A61K2800/10
Inventor 许敏陈淑霞韩佳欣李海舟杨崇仁
Owner KUNMING UNIV OF SCI & TECH
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