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Application of cedarwood essential oil

A technology of cedarwood essential oil and cedarwood, which is applied in the field of biomedicine, can solve the problems of large side effects, high price, and low medical treatment rate for CNS system diseases, and achieve the effects of reducing toxicity, improving cognitive function and good pharmacokinetic parameters.

Inactive Publication Date: 2019-08-16
东莞怀朴植物精油有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the domestic drug market for treating CNS-related diseases is dominated by imported drugs, and the price is too high for ordinary patients to bear. The economic problems caused by long-term use are also difficult to solve the problem of low medical treatment rate for CNS systemic diseases in my country.
At the same time, the existing drugs have relatively large side effects, and long-term use will cause a greater impact.

Method used

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  • Application of cedarwood essential oil
  • Application of cedarwood essential oil
  • Application of cedarwood essential oil

Examples

Experimental program
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Effect test

preparation example Construction

[0039] The preparation method of cedarwood essential oil of the present invention comprises steam distillation extraction, carbon dioxide supercritical extraction.

[0040] Cedarwood essential oil of the present invention detects with gas chromatography-mass spectrometry instrument, and its main components are α-cuprenene (α-cuprenene) (>30%), α-cis-cedrene (α -cis-himachalene) (>5%), γ-cis-cedrene (γ-cis-himachalene) (>3%).

Embodiment 1

[0042] Get Himalayan cedar (Cedrus deodara (Roxb.) G.Don) fresh or dry bark, stem, branch, leaf or fruit 100Kg, place in a heap for 2 days, crush to 50 mesh coarse particles, soak the coarse particles in 8 mass Double the amount of pH value of 5.0 hydrochloric acid aqueous solution, leaching overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain cedarwood essential oil.

Embodiment 2

[0044] Get Atlantic cedar (Cedrus atlantica (Endl.) Manetti ex Carrière) fresh or dry bark, stems, branches, leaves or fruit 120Kg, place in a heap for 2 days, crush to 50 mesh coarse particles, soak the coarse particles in 8 mass Double the amount of pH value of 5.0 hydrochloric acid aqueous solution, leaching overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain cedarwood essential oil.

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Abstract

The invention discloses application of cedarwood essential oil. The application of the cedarwood essential oil comprises application of the cedarwood essential oil to preparing brain function and disorder disease treating or preventing medicines and healthcare products. According to the application of the cedarwood essential oil, novel application of the cedarwood essential oil, which is highly active in treating brain function and disorder diseases in experimental animals, to preparing medicines and healthcare products is discovered for the first time; that the cedarwood essential oil or cedarwood essential oil-containing compositions can improve the symptoms of animals with brain function and disorder diseases such as senile dementia and depression and anxiety is also discovered for thefirst time. Compared with existing brain function and disorder treating medicines, the cedarwood essential oil or the cedarwood essential oil-containing compositions can have a mechanism of polymolecular synergistic effects on targets by inhibiting cholinesterase, regulating neurotransmitters and the like, achieve good pharmacokinetic parameters and easily penetrate through blood brain barriers, thereby having the advantages of toxicological safety, stable metabolism, a relatively long half-life period and relatively low side effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of cedarwood essential oil in the preparation of medicines and health products for treating and preventing brain function and its disorders. Background technique [0002] Brain function and its disorders (such as: anxiety, depression, insomnia, convulsions, mania, schizophrenia, spasticity, senile dementia, Parkinson's disease) are one of the main diseases that endanger human health. The mechanism of action of current therapeutic drugs mainly involves inhibiting the activity of enzymes, interfering with cell metabolism, reducing the inhibitory transmitter GABA, etc., or acting on G protein-coupled receptors or ion channels of cell membranes, affecting the release of neurotransmitters or interacting with synaptic neurotransmitters. Binding of post-synaptic membrane receptors, etc. However, the molecular mechanisms of most brain functions and their disorders have not b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61P25/28A61P25/00A61P9/10A61P21/00A23L33/105
CPCA23V2002/00A61K36/15A61K2236/19A23L33/105A61P9/10A61P21/00A61P25/00A61P25/28A23V2200/322A23V2250/21
Inventor 许敏韩佳欣曹海龙罗道玉郑三会李云辉顾培爽宋晖
Owner 东莞怀朴植物精油有限公司
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