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Preparation method of embedded resveratrol

A technology of adding methanol to resveratrol, which is applied in the field of composite materials, can solve the problems of not being suitable for large-scale industrial production and many application restrictions, and achieve good performance, improved absorption and utilization in the body, and good slow-release effect

Active Publication Date: 2019-08-09
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a preparation method for embedding resveratrol, which solves the technical problem that the existing method for embedding natural polyphenols is not suitable for large-scale industrial production and has many application restrictions

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0024] (1) Preparation of carboxymethyl-β-cyclodextrin

[0025] Pipette an appropriate amount of 25% sodium hydroxide solution into a round-bottomed flask, add a certain amount of β-CD (β-cyclodextrin), and stir to dissolve it completely. A certain amount of chloroacetic acid aqueous solution was added dropwise to the alkali solution of β-CD under stirring, and reacted at room temperature for 9h. After the reaction is complete, neutralize with dilute hydrochloric acid, adjust the pH of the system to 9, then add 80m L of methanol until the system no longer has white precipitates, leave it for 12 hours, filter, add water to dissolve the precipitates (precipitation and water volume keep 1:1), Methanol was added to this solution until no more precipitates formed, filtered and dried under vacuum at 80°C.

[0026] (2) Preparation of carboxymethyl-β-cyclodextrin chitosan hydrochloride nanoparticles

[0027] Prepare 1mg / mL chitosan hydrochloride aqueous solution with deionized water...

Embodiment 2

[0031] (1) Preparation of carboxymethyl-β-cyclodextrin

[0032] Pipette an appropriate amount of 25% sodium hydroxide solution in a round-bottomed flask, add a certain amount of β-CD, and heat and stir to completely dissolve it. A certain amount of chloroacetic acid aqueous solution was added dropwise to the alkali solution of β-CD under stirring, and reacted for 9 hours at room temperature. After the reaction is completed, neutralize with dilute hydrochloric acid, adjust the pH value of the system to 9, then add 80 mL of methanol until the system no longer produces white precipitates, leave it for 12 hours, filter, add water to dissolve the precipitates (precipitation and water volume keep 1: 1), and pour to Methanol was added to this solution until no more precipitates formed, filtered, and dried under vacuum at 80°C.

[0033] (2) Preparation of carboxymethyl-β-cyclodextrin chitosan hydrochloride nanoparticles

[0034] Prepare 1mg / mL chitosan hydrochloride aqueous solution...

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Abstract

The invention relates to the technical field of composite materials, in particular to a preparation method of embedded resveratrol. The preparation method of the embedded resveratrol is characterizedby comprising the following steps that 1, a chloroacetic acid aqueous solution is added to a beta-cyclodextrin alkali solution to obtain a mixed solution, methanol is added to the mixed solution, precipitation is carried out, and carboxymethyl-beta-cyclodextrin is obtained; 2, a chitosan hydrochloride solution is mixed with the carboxymethyl-beta-cyclodextrin, a glutaraldehyde solution is dropwiseadded, and stirring is carried out to obtain a carboxymethyl-beta-cyclodextrin chitosan hydrochloride nano solution; 3, the carboxymethyl-beta-cyclodextrin chitosan hydrochloride nano solution is mixed with a resveratrol solution, and a mixed solution is adjusted to be neutral to obtain the embedded resveratrol. The preparing method of the embedded resveratrol solves the technical problem that anexisting method for embedding natural polyphenols is not suitable for massive industrial production and has many application limitations.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to a preparation method for embedding resveratrol. Background technique [0002] Most of the natural polyphenols are easily destroyed and unstable under normal conditions. Therefore, people hope to improve the stability of the physical and chemical properties of natural polyphenols, improve their solubility, and control their release through structural modification, microcapsule technology, etc., so that they can be applied to industrial products. [0003] Microencapsulation technology is one of the high-tech that develops rapidly and is widely used today. Microcapsule technology refers to the technology of embedding gas, liquid or solid in tiny and sealed capsules so that they can be released at a controlled rate under specific conditions. A microcapsule is a small sphere that is evenly surrounded by material. The substance embedded in it is called the core material,...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/05A61P39/06A61P35/00A61P31/04A61P31/10
CPCA61K47/6951A61K47/6949A61K31/05A61P39/06A61P35/00A61P31/04A61P31/10
Inventor 黄梓浩王定国丁利君
Owner GUANGDONG UNIV OF TECH
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