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Protein marker for sicca syndrome in saliva and application of protein marker

A technology for Sjögren's syndrome and protein, applied in the biological field, can solve the problems of insufficient protein identification depth, evaluation, and lack of diagnostic accuracy.

Active Publication Date: 2019-08-02
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, the above studies still have certain limitations, such as lack of evaluation of diagnostic accuracy and insufficient depth of protein identification.

Method used

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  • Protein marker for sicca syndrome in saliva and application of protein marker
  • Protein marker for sicca syndrome in saliva and application of protein marker
  • Protein marker for sicca syndrome in saliva and application of protein marker

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Embodiment Construction

[0029] Below in conjunction with accompanying drawing, further illustrate the present invention through the embodiment, but not as limitation to the present invention. Specific materials and their sources used in embodiments of the invention are provided below. However, it should be understood that these are merely exemplary and not intended to limit the present invention, and materials identical or similar to the type, model, quality, property or function of the following reagents and instruments can be used to implement the present invention. The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0030] We screened Sjögren's syndrome-associated proteins in saliva with data independent acquisition (DIA).

[0031] Materials and Reagents

[0032] 1) Instrument: Orbitrap Fusion Lumos Tribrid mass ...

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Abstract

The invention relates to a protein marker for sicca syndrome in saliva and application of the protein marker. Particularly, the invention relates to application of a protein identification reagent inpreparation of a reagent for diagnosing the sicca syndrome in a subject. Protin is selected from a combination of acylamino acid release enzyme, 1,4-glucose formyl transfer enzyme, Calumenin, C-C motif chemotatic factor ligand 28, activation-induced cytidine deaminase, alpha collagen 1 chain, carboxypeptidase D, carboxypeptidase E, cysteine proteinase inhibitor C, cathepsin L, DnaJ heat shock protein family (Hsp40) member C3, furan paired basic amino acid lyase, HtrA serine peptidase 1, kallikrein correlated peptidase 11, trypsin 3, proteasome subunit-4, proteasome subunit 9, antichymotrypsinand vimentin.

Description

technical field [0001] The invention relates to the field of biotechnology, more specifically to a protein marker of Sjögren's syndrome in saliva and its application in early diagnosis. Background technique [0002] Sjögren's syndrome (SS) is a chronic autoimmune disease that mainly invades exocrine glands. It can be divided into primary and secondary types. Clinically, salivary gland and lacrimal gland involvement are the main clinical manifestations. Primary Sjogren's syndrome refers to Sjögren's syndrome without another diagnosed autoimmune disease. Secondary Sjögren's syndrome refers to Sjögren's syndrome combined with another autoimmune disease such as rheumatoid arthritis and systemic lupus erythematosus. The global prevalence of Sjögren's syndrome is between 0.5-2.0%, with 90% being female (see, e.g., S. Gonzalez, H. Sung, D. Sepulveda, M. Gonzalez, C. Molina, Oral manifestations and their treatment in Sjogren's syndrome, Oral diseases, 20(2014) 153-161). About 5%-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6848G01N33/6893
Inventor 孙伟孙海丹刘晓燕
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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