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Antimicrobial peptide and application thereof

A technology of antibacterial peptides and antibacterial agents, applied in the field of drug application, can solve the problems of increasing the dosage and course of treatment, harm, environmental pollution, etc., and achieve the effects of reducing residues, inhibiting proliferation, and reducing pollution

Active Publication Date: 2019-08-02
ANYANG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of antibiotics such as penicillin and streptomycin have been used clinically, leading to the emergence of some drug-resistant strains, which requires continuous increase in the dosage and course of treatment, causing greater pollution and harm to the environment

Method used

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  • Antimicrobial peptide and application thereof
  • Antimicrobial peptide and application thereof
  • Antimicrobial peptide and application thereof

Examples

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Embodiment Construction

[0023] A new antimicrobial peptide involved in the present invention and its preparation method and application will be described in detail below in conjunction with the accompanying drawings. Those skilled in the art should understand that the embodiments described below are only for better understanding of the present invention, and are not intended to limit the present invention.

[0024] The new antimicrobial peptide provided by the present invention comes from armyworm. The armyworm collected in the field is sent to a sequencing company for sequencing, and the antimicrobial peptide gene sequence is found by comparing the sequences obtained by sequencing the armyworm transcriptome. Such as figure 1 As shown, the length of the gene encoding the new antimicrobial peptide is 192 bp, and the antimicrobial peptide contains 63 amino acid residues. Compared with similar antimicrobial peptides, it is found that the antimicrobial peptide contains a conserved cleavage site, and the...

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Abstract

The invention discloses an antimicrobial peptide. A gene sequence of the antimicrobial peptide is shown as sequence table SEQ ID No.1; an amino acid sequence of the antimicrobial peptide is shown as sequence table SEQ ID No.2; a mature polypeptide sequence of the antimicrobial peptide is shown as sequence table SEQ ID No.3. By identifying the antimicrobial peptide from armyworm body and performingin vitro chemical synthesis, the invention finds that the in vitro prepared antimicrobial peptide Cecropin has an excellent antibacterial effect to escherichia coli; a basis is established for developing an antibiotic substitute for treating escherichia coli, so that the pollution to animal by-products and environment caused by the usage of mass antibiotics can be reduced.

Description

technical field [0001] The invention belongs to the technical field of drug application, and in particular relates to an antibacterial peptide and its application. Background technique [0002] Antimicrobial peptides (AMPs) are small molecular substances that widely exist in organisms and are an important barrier for the body's immunity. They can directly or indirectly kill pathogenic microorganisms by regulating the body's immune system. Studies have shown that AMPs have various biological activities such as anti-virus, anti-bacteria, anti-fungal, anti-protozoal, anti-tumor, and participate in immune regulation. Antimicrobial peptides have many characteristics, such as small molecules, strong water solubility, good stability, etc., and do not have antigenicity, but some AMPs have hemolytic activity and other shortcomings. Cecropin was the first AMPs discovered. Since then, a variety of AMPs have been identified by researchers, and the extraction, in vitro expression, and ...

Claims

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Application Information

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IPC IPC(8): C12N15/12C07K14/435A61K38/17A61P31/04A23L33/18A23K20/147
CPCC07K14/43563A61P31/04A23L33/18A23K20/147A61K38/00Y02A50/30
Inventor 连凯琪周玲玲张明亮张元臣宋玉伟王英杰蔡新
Owner ANYANG INST OF TECH
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