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Chemical exchange saturation transfer imaging method for eliminating fat artifact

A technology of chemical exchange and transfer imaging, used in medical science, diagnosis, measurement of magnetic variables, etc.

Active Publication Date: 2019-07-30
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These inherent defects make chemical exchange magnetization transfer imaging of the body still affected by fat artifacts

Method used

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  • Chemical exchange saturation transfer imaging method for eliminating fat artifact
  • Chemical exchange saturation transfer imaging method for eliminating fat artifact
  • Chemical exchange saturation transfer imaging method for eliminating fat artifact

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0046] This embodiment is the mammary gland data of a healthy and normal volunteer, and the data comes from a Siemens 3.0T magnetic resonance imaging system. For the chemical exchange saturation transfer imaging sequence used see figure 1 .

[0047] The image acquisition part includes the following steps:

[0048] Step 1: The data acquisition of chemical exchange saturation transfer imaging is to obtain the mode map and phase map of magnetic resonance imaging by using the multi-echo gradient echo sequence of the monopolar readout gradient under the irradiation of saturated radio frequency at different frequencies. Irradiation parameters: from -6ppm to +6ppm, a total of 31 frequency offsets. Saturation pulse duration 200ms, number of saturation pulses 6. Image acquisition parameters: TR / TE1 / ΔTE=11.0 / 2.3 / 1.5ms, number of echoes=5, flip angle=8°, FOV=320×320mm 2 , matrix size=128×128, voxel size=2.5×2.5mm 2 , layer thickness = 6mm.

[0049] Step 2: The reference data acquisi...

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Abstract

The invention discloses a chemical exchange saturation transfer imaging method for eliminating fat artifacts, which comprises the steps of image acquisition and image reconstruction, wherein the imageacquisition is to acquire a model image and a phase image of magnetic resonance imaging by adopting a multi-echo gradient echo sequence under the condition of unsaturated radio frequency irradiationand the condition of saturated radio frequency irradiation of different frequencies; the image reconstruction comprises reconstructing a water map, a fat map, a field map and a map based on data collected under irradiation of the multimodal fat model on unsaturated radio frequency; fat models in data acquired after saturated radio frequency irradiation of different frequencies is updated on a per-entity basis by using a numerical method; a water map and a fat map are reconstructed based on the data acquired by the updated fat model under the saturated radio frequency irradiation of different frequencies; and the accurate water-fat reconstruction ensures that no fat signal interference exists in the water map, fat artifacts occurring in chemical exchange saturation transfer imaging are effectively eliminated, and the chemical exchange saturation transfer imaging method for eliminating fat artifacts can improve the accuracy of the chemical exchange saturation transfer imaging.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a chemical exchange saturation transfer imaging method for eliminating fat artifacts. Background technique [0002] Chemical exchange magnetization transfer imaging technology is a molecular imaging technology in the field of magnetic resonance imaging technology. When the exchangeable protons in exogenous or endogenous molecules are saturated by frequency-selective radiofrequency, the saturation effect can be transferred to the protons of free water through chemical exchange, and finally the molecules containing exchangeable protons can be affected indirectly based on the change of water signal. for imaging. As a molecular-level imaging technique, chemical exchange magnetization transfer imaging technology provides molecular-level histopathological information for disease diagnosis, such as the concentration of imaging target molecules, tissue pH, and local t...

Claims

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Application Information

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IPC IPC(8): G01R33/565A61B5/055
CPCA61B5/055G01R33/565
Inventor 赵羽李建奇
Owner EAST CHINA NORMAL UNIV
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