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A self-assembled antibacterial coating based on nano-silver/d-cysteine ​​and its preparation method

A cysteine, antibacterial coating technology, applied in coating, medical science, prosthesis and other directions, can solve the problem of unclear mechanism of action, silver poisoning and other problems, achieve easy preparation, less side effects, coating adhesion high effect

Active Publication Date: 2020-10-13
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the antibacterial effect of nano-silver is remarkable, its mechanism of action is still unclear, and the free state of silver is easily phagocytized by cells and causes poisoning. Therefore, attention should be paid to its biocompatibility in practical applications.

Method used

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  • A self-assembled antibacterial coating based on nano-silver/d-cysteine ​​and its preparation method
  • A self-assembled antibacterial coating based on nano-silver/d-cysteine ​​and its preparation method
  • A self-assembled antibacterial coating based on nano-silver/d-cysteine ​​and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Sand the 316L stainless steel with a size of 10mm×10mm×3mm to 1500# with sandpaper, then ultrasonically clean it with acetone and alcohol in sequence and dry it in the air.

[0028] 2. Use Tris solution to prepare 2 mg / ml dopamine solution, and titrate the pH to 8.5. Put 316L stainless steel into the dopamine solution, and the solution submerges about 20mm above the top of the sample. Put the solution into a shaker, set the speed at 42rpm, and soak for 24h.

[0029] 3. Ultrasonic the sample taken out to remove the unstable dopamine particles attached to the surface, then put the sample in 5 mg / L silver nitrate solution, shield it with tin foil, and soak for 5 hours.

[0030] 4. Rinse the sample taken out with deionized water and put it in 10 -3 mg / ml D-cysteine ​​solution, soak for 5 hours, take it out, rinse with deionized water, and dry naturally.

[0031] Figure 1a It is the scanning electron micrograph of the novel self-assembled antibacterial coating based o...

Embodiment 2

[0033] 1. Sand the base material titanium alloy with a size of 10mm×10mm×3mm to 1500# with sandpaper, then ultrasonically clean it with acetone and alcohol in sequence and dry it in the air.

[0034] 2. Use Tris solution to prepare 2 mg / ml dopamine solution, and titrate the pH to 8.5. Put the titanium alloy into the dopamine solution, and the solution submerges about 20mm from the top of the sample. Put the solution into a shaker, set the speed to 40rpm, and soak for 20h.

[0035] 3. Ultrasonic the sample taken out to remove the unstable dopamine particles attached to the surface, then put the sample into 1 mg / L silver nitrate solution, shield it with tin foil, and soak for 5 hours.

[0036] 4. Rinse the sample taken out with deionized water and put it in 5×10 -3 mg / ml D-cysteine ​​solution, soak for 5 hours, take it out, rinse with deionized water, and dry naturally.

[0037] Fig. 3 is the antibacterial effect diagram of the novel self-assembled antibacterial coating based...

Embodiment 3

[0039] 1. Sand the base material magnesium alloy with a size of 10mm×10mm×3mm to 1500# with sandpaper, then ultrasonically clean it with acetone and alcohol in sequence and dry it in the air.

[0040]2. Use Tris solution to prepare 2 mg / ml dopamine solution, and titrate the pH to 8.5. Put the titanium alloy into the dopamine solution, and the solution submerges about 20mm from the top of the sample. Put the solution into a shaker, set the speed at 30rmp, and soak for 24h.

[0041] 3. Ultrasonic the sample taken out to remove the unstable dopamine particles attached to the surface, then put the sample in 3 mg / L silver nitrate solution, shield it with tin foil, and soak for 5 hours.

[0042] 4. Rinse the sample taken out with deionized water and put it in 10 -2 mg / ml D-cysteine ​​solution, soak for 5 hours, take it out, rinse with deionized water, and dry naturally.

[0043] Fig. 4 is the antibacterial effect diagram of the self-assembled antibacterial coating based on nano-s...

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Abstract

The invention discloses a method for preparing a nano-silver / D-cysteine antibacterial coating on the surface of medical metal. The method comprises the steps that the medical metal is sequentially subjected to ultrasonic treatment through acetone, ethyl alcohol and deionized water; a dopamine solution is prepared, the medical metal is put in the dopamine solution for soaking, after the medical metal is taken out, dopamine particles which are not stably attached to the surface are subjected to ultrasonic removal, then the medical metal is put in a silver nitrate solution for soaking, and then apoly-dopamine-nano-silver coating is formed on the surface of medical metal; afterwards, the medical metal loaded with the nano-silver particles is put in a D-cysteine solution for a reaction to obtain the nano-silver / D-cysteine antibacterial coating. The composite nano-structure prepared by means of the method is simple and feasible in technology, and has the functions of efficient spectral bacterial resistance and biomembrance adhesion resistance; meanwhile, the nano-silver / D-cysteine antibacterial coating has good biocompatibility, and has very important application value in developing novel in-vivo implant materials.

Description

technical field [0001] The invention relates to the technical field of medical antibacterial coatings and nanometer materials, in particular to a nano-silver / D-cysteine-based self-assembled antibacterial coating and a preparation method. Background technique [0002] Medical surgical instruments, implantable instruments such as artificial titanium alloy bones, biomedical stainless steel, etc., often suffer from infection after surgery or implantation, resulting in infection or even failure of the implant. At the same time, it is difficult to find the initial signs of infection. It is often necessary to perform the operation again, which will cause great physical and psychological trauma to the patient. [0003] Due to its unique properties, silver nanoparticles have been reported in the research of antibacterial materials, medical devices and other fields. Although the antibacterial effect of nano-silver is remarkable, its mechanism of action is still unclear, and free silv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/04A61L27/06A61L27/30
CPCA61L27/047A61L27/06A61L27/306A61L27/54A61L2300/104A61L2300/214A61L2300/404A61L2300/45A61L2300/606
Inventor 张达威黄路遥娄云天钱鸿昌李晓刚
Owner UNIV OF SCI & TECH BEIJING
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