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Antibacterial hydrogel containing organic quaternary ammonium salt or silane terminated organic quaternary ammonium salt and preparation method thereof

An organic quaternary ammonium salt and hydrogel technology, applied in bandages, medical science, etc., can solve the problems of obvious side effects and inability to use for a long time, achieve long-lasting antibacterial properties, sterilize or inhibit bacterial growth, and enhance effective antibacterial effects

Pending Publication Date: 2019-07-30
董英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these antibacterial hydrogels are also very effective, such products cannot be used for a long time, with obvious side effects and pigmentation
It is extremely challenging to treat patients with extensive burns and acute and chronic deep wound infections

Method used

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  • Antibacterial hydrogel containing organic quaternary ammonium salt or silane terminated organic quaternary ammonium salt and preparation method thereof
  • Antibacterial hydrogel containing organic quaternary ammonium salt or silane terminated organic quaternary ammonium salt and preparation method thereof
  • Antibacterial hydrogel containing organic quaternary ammonium salt or silane terminated organic quaternary ammonium salt and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Product formula (mass ratio%):

[0024]

[0025] Preparation:

[0026] Mix polyvinylpyrrolidone, polyvinyl alcohol, silane-terminated organic quaternary ammonium salt, purified water, and PEG 400 uniformly at a temperature of 65°C, and stir for 24 hours to prepare a hydrogel preparation solution; in step (1) Sodium citrate dihydrate and organic acid are added to the hydrogel gel preparatory solution, and after being uniform and transparent, they are added to a stirring pot, and auxiliary components are added, stirred and homogenized to obtain a hydrogel solution containing antibacterial materials;

[0027] The hydrogel solution containing the antibacterial material prepared in step (2) is sterilized by irradiation to obtain the finished antibacterial hydrogel.

Embodiment 2

[0029] Product formula (mass ratio%):

[0030]

[0031] Preparation:

[0032] Mix polyvinylpyrrolidone, polyvinyl alcohol, silane-terminated organic quaternary ammonium salt, purified water, and PEG400 uniformly at a temperature of 65°C, and stir for 24 hours to obtain a hydrogel preparation solution; in step (1), the water Sodium citrate dihydrate and organic acid are added to the gel preparatory solution, and after being uniform and transparent, they are added to a stirring pot, and auxiliary components are added, stirred and homogenized to obtain a hydrogel solution containing antibacterial materials;

[0033] The hydrogel solution containing the antibacterial material prepared in step (2) is sterilized by irradiation to obtain the finished antibacterial hydrogel.

Embodiment 3

[0035] Product formula (mass ratio%):

[0036]

[0037] Propylene glycol, glycerin, stearyl alcohol, purified water, alkyl dimethyl benzyl ammonium chloride, 3-(3 methoxysilyl) propyl dimethyl octadecyl ammonium chloride at a temperature of 65°C Mix evenly, adjust the pH to 2.0-6.5, and stir for 24 hours to prepare a hydrogel preparatory solution; then add disodium EDTA to the preparatory solution and stir evenly to prepare an amorphous hydrogel.

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Abstract

The invention relates to the technical field of antibacterial hydrogel manufacturing, in particular to an antibacterial hydrogel containing organic quaternary ammonium salt or silane terminated organic quaternary ammonium salt and a preparation method thereof. The hydrogel is characterized by being prepared from, by mass, 0.1-65% of 3-(3 methoxy-silicyl)propyl dimethyl octadecyl ammonium chlorideor alkyl dimethyl benzyl ammonium chloride. Compared with the prior art, the hydrogel has the broad-spectrum antibacterial effect and the long-lasting antibacterial performance, is applicable to wounddebridement and wound dressing and has no toxic or side effect and high adhesion force and other remarkable advantages.

Description

[0001] Technical field: [0002] The invention relates to the technical field of antimicrobial hydrogel manufacturing, in particular to a hydrogel containing broad-spectrum antibacterial effect and long-lasting antibacterial performance, which is suitable for wound debridement and wound dressing, has no irritation to the skin, no toxic side effects, and strong adhesion. Organic quaternary ammonium salt or organic quaternary ammonium salt with silane end antibacterial hydrogel and preparation method thereof. [0003] Background technique: [0004] Hydrogel is a three-dimensional network formed by hydrophilic polymers. Because its three-dimensional network structure is similar to the structure of natural extracellular matrix, hydrogel has very attractive biomimetic properties and very good Biocompatibility, formally due to these characteristics, hydrogels are widely used in various fields of regenerative medicine, for treating unsatisfactory wounds with granulation tissue formati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0019A61L26/0066A61L26/008A61L2300/208A61L2300/404C08L29/04C08L71/02
Inventor 董英
Owner 董英
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