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Application of glaucocalyxin A in preparation of drug for treating lung cancer

A technology of Wangzaozi B and its uses, which is applied in the fields of biochemistry and molecular biology, can solve the problems of complex pathological mechanisms and have not been clearly explained, and achieve the effect of promoting expression

Inactive Publication Date: 2019-07-30
DALIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

NSCLC is the most common form of lung cancer and has complex pathological mechanisms that have not been clearly elucidated so far

Method used

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  • Application of glaucocalyxin A in preparation of drug for treating lung cancer
  • Application of glaucocalyxin A in preparation of drug for treating lung cancer
  • Application of glaucocalyxin A in preparation of drug for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Example: Extraction and Verification of Wangzaozi B

[0026] Refer to CN105585471A to extract and verify Wangzaozi B. Briefly, the extraction steps are as follows: (1) The root of Wangzaozi is crushed with an ordinary pulverizer, and passed through a 40-mesh sieve to obtain the coarse powder of Wangzaozi root; (2) Accurately weigh the root of Wangzaozi Coarse powder 5.0kg, add 60gNaHCO 3 Mix the additives evenly, grind them in a super mill for 40 minutes, pass through a 300-mesh sieve, accurately weigh 2.0 kg and put them in a beaker, add 80% ethanol aqueous solution according to the ratio of material to liquid 1:24, and stir evenly; (3 ) was ultrasonically extracted at 45°C, frequency 43kHz, and power 250W for 50 minutes, and the extract was vacuum filtered to obtain a filtrate, which was concentrated under reduced pressure at 40°C and 60r / min to obtain a concentrate; (4) the concentrate was sequentially Through petroleum ether and chloroform extraction; (5) take the ...

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Abstract

The invention discloses application of glaucocalyxin A in preparation of a drug for treating lung cancer. Particularly, the glaucocalyxin A acts on lung cancer cells, cell apoptosis can be induced bydestroying mitochondrial membrane potential, causing Cyto-C outflow, inhibiting anti-apoptosis protein Bcl-2, promoting pro-apoptotic protein Bax expression and causing Caspase cascade reactions, anda choice of a new treatment drug is provided for lung cancer treatment.

Description

technical field [0001] The invention belongs to the technical field of biochemistry and molecular biology, and specifically relates to the use of wangzaozi B in the preparation of medicines for treating lung cancer. Background technique [0002] Lung cancer (lung cancer, LC) is called primary bronchial carcinoma. It is a disease that is deficient in the whole body and true in the local area. It originates from the malignant tumor of the bronchial mucosa or glands. The five-year survival rate of lung cancer is extremely low, and its morbidity and mortality rank first in my country. [0003] According to the degree of differentiation and morphological characteristics of lung cancer, lung cancer is divided into two categories: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), and NSCLC includes squamous cell carcinoma and adenocarcinoma and large cell carcinoma. SCLC is a highly aggressive neuroendocrine tumor characterized by early metastasis, rapid progr...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P35/00
CPCA61K31/122A61P35/00
Inventor 薛宏宇连显会苗诗雨牛蕾王宁周玉荣刘亚军姜丽丽刘勇
Owner DALIAN UNIV OF TECH
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