Apparatus and method for producing 3-acetyl-1-propanol by continuous hydrogenation of 2-methylfuran

Abstract

The invention relates to the field of chemical industry, in particular to an apparatus and method for producing 3-acetyl-1-propanol by continuous hydrogenation of 2-methylfuran. The method comprises metering a mixture of water, a solvent and 2-methylfuran with a metering pump, feeding the metered mixture and metered hydrogen into a reactor, processing with an atomizer, holding certain temperatureand pressure, carrying out hydrogenation in a fixed bed in the atomized state, discharging the reacted liquid directly into a gas-liquid separator, wherein the discharged liquid is in gas-liquid mixedform, discharging the liquid part from the bottom of the gas-liquid separator after the discharge liquid enters the gas-liquid separator, neutralizing with a secondary reactor, and carrying out subsequent distilling and rectifying; processing hydrogen from the upper portion of the gas-liquid separator through a condenser, further cooling residual liquid in the reacted liquid, reserving in a liquid phase, and feeding non-condensed hydrogen into a hydrogen compressor through a hydrogen return pipe for reuse. The feeding quantity is controlled via the metering pump; the discharging quantity is controlled through a liquid level in the gas-liquid separator; therefore, balance is maintained.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to equipment and a method for continuously hydrogenating 2-methylfuran to produce acetyl n-propanol. Background technique [0002] Acetyl n-propanol is an important pharmaceutical intermediate, the main intermediate of the anti-AIDS drugs efavirenz and irremin, used in the antimalarial drug chloroquine phosphate, and can also be used in the production of vitamin B1, etc., and is also used for sterilization Intermediates of cyprodinil and cyproconazole [0003] At present, there are mainly three kinds of production processes of acetyl n-propanol: two kinds are involved in the handbook of fine organic chemical raw materials and intermediates_[Xu Kexun_editor-in-chief]: one is the catalytic hydrogenation method of 2-methylfuran palladium chloride, which reacts The cycle is very long (about 120 hours per batch), and the industrialization efficiency is low; the second is the γ-butyrolac...

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Problems solved by technology

[0003] At present, there are mainly three kinds of production processes of acetyl n-propanol: two kinds are involved in the handbook of fine organic chemical raw materials and intermediates_[Xu Kexun_Editor-in-Chief]: one is the catalytic hydrogenation method of 2-methylfuran palladium chloride, which reacts The cycle is very long (about 120 hours per batch), and the industrialization efficiency is low; the second is the γ-butyrolactone method, which requires a high reaction temperature (350-390°C), and has high requirements for equipment performance and safety;

[0004] The third is that 2-methylfuran in the Chinese patent CN102140058A uses intermittent catalytic hydrogenation of palladium carbon catalyst to produce acetyl n-propanol. This method is simple to operate, easy to control, mild in reaction conditions, and suitable for industrial production, but because it is an intermittent reaction, Each batch needs to be operated separately, the intermediate material transfer link is cumbersome, hydrogen replacement wastes hydrogen and reduces efficiency

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