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Externally applied medicinal composition for treating neonatal dermatosis, preparation method and use method thereof

A technology of externally used drugs and compositions, applied in the direction of drug combinations, skin diseases, medical preparations containing active ingredients, etc., can solve the problems of not advising to use it on newborns, easy to relapse, unsuitable for newborns, etc., to reduce resistance The production of drug strains, high cure rate and effective rate, and no adverse reactions

Inactive Publication Date: 2019-07-26
QINGDAO WOMEN & CHILDREN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But among the above-mentioned external medicines, calamine lotion can only slightly relieve itching, and cannot completely cure the disease; alcohol can cause severe allergic reactions, and should not be used for newborns; erythromycin ointment and Bactobang cream are only It is used for skin infection, and it is an antibiotic, so there are many adverse reactions; prickly heat powder can only relieve itching, and it is not recommended to be used for newborns at present; burn ointment cannot fight infection, and it is used for burns and large areas of skin abrasions Sometimes the curative effect is not satisfactory; corticosteroids, although quick to take effect, are prone to relapse after drug withdrawal, and will produce side effects such as pigmentation, dry skin, atrophy, and telangiectasia. Long-term use may cause damage to the hypothalamus-pituitary-adrenal axis. Inhibition; other preparations containing lead and boric acid may be poisoned, and most of them are not suitable for use
[0004] Based on the above analysis, it can be seen that the currently used drugs are far from meeting the clinical needs, so there is an urgent need to develop drugs with good effects, quick results, and no toxic side effects, so as to avoid the abuse of antibiotics

Method used

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  • Externally applied medicinal composition for treating neonatal dermatosis, preparation method and use method thereof
  • Externally applied medicinal composition for treating neonatal dermatosis, preparation method and use method thereof
  • Externally applied medicinal composition for treating neonatal dermatosis, preparation method and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The external pharmaceutical composition for treating neonatal skin diseases consists of the following raw materials in parts by mass: 20 g of sophora flavescens, 18 g of purslane, 15 g of honeysuckle, and 10 g of white ox gallbladder.

[0032] The preparation method comprises the following steps: weighing sophora flavescens, purslane, honeysuckle and white ox gallbladder, grinding and crushing, the particle size range is 40-50 mesh, soaking in pure water for 30 minutes; then, adding pure water to make up the system to 500ml, simmering Decoct for 30-40 minutes to obtain about 250ml of liquid medicine; cool down to room temperature, subpackage, and set aside.

Embodiment 2

[0034] The external pharmaceutical composition for treating neonatal dermatosis is composed of the following raw materials in parts by mass: 30g of sophora flavescens, 27g of purslane, 25g of honeysuckle, and 20g of white ox gallbladder.

[0035] The preparation method is the same as in Example 1.

Embodiment 3

[0037] The pharmaceutical composition for external use for treating neonatal skin disease consists of the following raw materials in parts by mass: 20 g of sophora flavescens, 20 g of purslane, 20 g of honeysuckle, and 10 g of white ox gallbladder.

[0038] The preparation method is the same as in Example 1.

[0039] Animal experiment-rash model (adopting embodiment 1 formula)

[0040] 1. Animals

[0041] 48 clean-grade KM mice, half male and half male, 25-30 g each, were purchased from Qingdao Animal Center. During the experiment, all mice were normally fed with feed and water without special experimental requirements, the growth environment temperature was 22±2 degrees, the humidity was 50-60%, and the circadian rhythm was 12-12 hours.

[0042] 2. Grouping

[0043] 48 mice were weighed after feeding for 1 week to ensure that there was no statistical difference in weight change, and then they were randomly divided into 6 groups, which were blank control group, model group,...

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PUM

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Abstract

The invention provides an externally applied medicinal composition for treating neonatal dermatosis, a preparation method and an application method thereof and belongs to the technical field of traditional Chinese medicine preparations. The medicinal composition has the effects of clearing away heat and toxic materials, eliminating dampness and relieving itching, and has mild medicinal properties,can be effectively applied in the treatment of neonatal skin diseases, has high cure rate and high efficiency, and has no adverse reactions during the treatment. The externally applied medicinal composition comprises, by mass: 15-30 g of radix sophorae flavescentis, 15-30 g of horseradish, 15-30 g of honeysuckle flowers and 10-20 g of compositae Inula cappa. The externally applied medicinal composition is high in safety, free of adverse reactions, free of gastrointestinal tract, liver and kidney function damage, and can be effectively used for treating neonatal skin problems such as neonatalimpetigo, neonatal toxic erythema, neonatal acute subacute eczema, scald and red swelling pain caused by skin damage.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to an external pharmaceutical composition for treating neonatal skin diseases, a preparation method and an application method thereof. Background technique [0002] Newborns have thin skin and low immunity, and stimuli such as humidity and heat can easily cause skin problems, which can lead to skin infections. The incidence of neonatal infectious rash (7.17%) and neonatal non-infectious rash (39.01%) was as high as 46.18%. However, due to the high safety requirements of newborn drugs, the application of many drugs is limited. [0003] At present, external medicines for the treatment of neonatal skin infections, allergic skin diseases, abrasions, burns, bedsores and other skin problems mainly include calamine lotion, prickly heat powder, alcohol, burn ointment, erythromycin ointment, Bactobang Cream, hormone, zinc boron cream, etc. But...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P17/00A61P17/02A61P29/00
CPCA61K9/0014A61K36/185A61K36/28A61K36/355A61K36/489A61K2236/15A61K2236/331A61P17/00A61P17/02A61P29/00A61K2300/00
Inventor 赵娜陈真真
Owner QINGDAO WOMEN & CHILDREN HOSPITAL
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