Preparation method of bone scaffold having anti-infection characteristic

Abstract

The invention provides a preparation method of a bone scaffold having an anti-infection characteristic. Mesoporous nanometer hydroxylapatite is used as a carrier of vancomycin, high vancomycin load capacity of the mesoporous nanometer hydroxylapatite and functions of the vancomycin for restraining bacterium growth and preventing infection are utilized, anti-infection effects of carboxymethyl chitosan and nanometer silver in various degrees are combined, vancomycin-loaded mesoporous nanometer hydroxylapatite and silver-carboxymethyl chitosan mixed powder is used as a base material, and the bonescaffold having the anti-infection characteristic is prepared through a three-dimensional printed quick shaping technique; and in the preparation course, the scaffold is modified through Type I collagen, and the biocompatibility of the scaffold is improved.

Description

technical field [0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a preparation method of a bone bracket with anti-infection properties. Background technique [0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common. In the process of traumatic bone defect repair, infection is very easy to occur, and the success of bone replacement grafting is closely related to infection. The treatment of infected bone defects has always been a clinical problem in orthopedics because it needs to repair the bone defect and prevent infection. After infection, bacteria form a biofilm on the surface of the implant, which makes the simple bone grafting fail because the infection is not easy to control. Therefore, patients often cannot perform primary bone grafting, but must thoroughly debride the wound. After the infection factors are eliminated, the wound h...

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the use of vancomycin-loaded mesoporous nano-hydroxyapatite and silver-carboxymethyl chitosan mixed powder as the matrix material, combined with collagen-polyvinyl alcohol binder to prepare anti-infective properties. Artificial bone scaffold, which effectively guarantees the anti-infection properties of the bone scaffold under the condition of satisfying the mechanical properties and biocompatibility of the bone scaffold