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Traditional Chinese medicine composition for treating advanced non-small cell lung cancer and preparing method and application thereof

A technology for non-small cell lung cancer and composition, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve problems such as poor curative effect, difficulty in early diagnosis and treatment of lung cancer, and difficulty in obtaining curative effects.

Inactive Publication Date: 2019-07-12
THE AFFILIATED HOSPITAL TO CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, early diagnosis and treatment of lung cancer are relatively difficult, and most patients with non-small cell lung cancer are already in the middle and advanced stages when they are diagnosed. Platinum-based first-line chemotherapy is still the main treatment for patients with unresectable non-small cell lung cancer. However, its toxic side effects are severe. , while killing cancer cells, it is easy to kill normal cells in the body. Immunosuppression is one of the important side effects of lung cancer chemotherapy, and its 5-year survival rate is only 18%.
Modern medical treatment measures for advanced non-small cell lung cancer are difficult to achieve satisfactory curative effect, and there are disadvantages such as poor curative effect, poor prognosis, and large side effects

Method used

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  • Traditional Chinese medicine composition for treating advanced non-small cell lung cancer and preparing method and application thereof
  • Traditional Chinese medicine composition for treating advanced non-small cell lung cancer and preparing method and application thereof
  • Traditional Chinese medicine composition for treating advanced non-small cell lung cancer and preparing method and application thereof

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preparation example Construction

[0037] The present invention also provides a preparation method of the Chinese medicine composition, comprising the following steps: mixing the raw materials according to the weight parts to obtain a Chinese medicine mixture; mixing the Chinese medicine mixture and water at a mass ratio of 1:6-8 Mixing, decocting, and filtering to obtain a Chinese medicine liquid; concentrating the Chinese medicine liquid to a relative density of 1.30-1.35 extract, drying under reduced pressure, and pulverizing into a Chinese medicine composition powder.

[0038] In the preparation method of the present invention, the decoction is preferably carried out under natural pressure, and the temperature of the decoction is preferably 70-100°C, more preferably 100°C. The decocting in the present invention is preferably carried out 2 to 3 times, and the time of each decocting is 1.8 to 2.5 hours, more preferably 2 hours. In the present invention, after each decoction, the decocted filter residue is col...

Embodiment 1

[0043] Weigh 5g ginseng, 20g astragalus, 5g Radix Radix, 5g Ophiopogon japonicus, 5g tangerine peel, 5g Pinellia, 5g Fritillaria, 5g Angelica, 3g Sanqi, 10g Scutellaria barbata, 20g Hedyotis diffusa, 10g Poria cocos, Atractylodes macrocephala 5g, Fritillaria 5g, Coix Seed 20g, Aster 5g, Baibu 5g, Bellflower 5g, Radix Licorice 5g, add 6 times the amount of water, decoct 3 times under natural pressure, 2 hours each time, filter the decoction, Combine the filtrates, concentrate to a relative density of 1.20-1.25 (60°C) extract, add appropriate amount of auxiliary materials, make soft materials, sieve, dry, and make granules. The content of active ingredients in the granules is ginsenoside Rg1 and ginsenoside The total content of Re is 0.03%, the content of ginsenoside Rb1 is 0.015%, and the content of astragaloside IV is 0.14%.

Embodiment 2

[0045] Weigh 10g of ginseng, 30g of astragalus, 10g of sand ginseng, 10g of radix japonicus, 10g of tangerine peel, 10g of pinellia, 10g of fritillaria, 10g of angelica, 5g of notoginseng, 15g of Scutellaria barbata, 30g of Hedyotis diffusa, 15g of poria, and Atractylodes macrocephala. 10g, Fritillaria 10g, Coix Seed 30g, Aster 10g, Baibu 10g, Campanulaceae 10g, Roasted Licorice 10g, add 7 times the amount of water, decoct 3 times under natural pressure, 2 hours each time, filter the decoction, Combine the filtrates, concentrate to a relative density of 1.30-1.35 (80°C) extract, dry under reduced pressure, and grind into a fine powder. Auxiliary materials are added to form tablets, and the active ingredient content is 0.03% of ginsenoside Rg1 and ginsenoside Re, 0.016% of ginsenoside Rb1 and 0.15% of astragaloside IV.

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Abstract

The invention provides a traditional Chinese medicine composition for treating the advanced non-small cell lung cancer and a preparing method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition comprises, by weight, 5-15 parts of ginseng, 20-40 parts of radix astragali, 5-15 parts of radix adenophorae, 5-15 parts of radix ophiopogonis, 5-15 parts of dried tangerine peel, 5-15 parts of pinellia ternata, 5-15 parts of bulbus fritillariae cirrhosae, 5-15 parts of radix angelicae sinensis, 3-7 partsof pseudo-ginseng, 10-20 parts of barbed skullcap herb, 20-40 parts of oldenlandia diffusa, 10-20 parts of poria cocos, 5-15 parts of rhizoma atractylodis macrocephalae, 5-15 parts of thunberg fritillary bulb, 20-40 parts of semen coicis, 5-15 parts of aster, 5-15 parts of radix stemonae, 5-15 parts of platycodon grandiflorum and 5-15 parts of honey-fried licorice root. With the traditional Chinese medicine theory as the guidance, according to the treatment rule of tonifying qi and yin, promoting blood circulation to remove phlegm, and removing toxic materials and stasis, the traditional Chinese medicine composition is mild in medicine property, strict in compatibility, clear in pharmacodynamics matter and remarkable in clinical treatment effect when used for treating the advanced non-small cell lung cancer.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating advanced non-small cell lung cancer, a preparation method and application thereof. Background technique [0002] Lung cancer, or primary bronchogenic carcinoma, is a malignant tumor originating from respiratory epithelial cells (bronchi, bronchioles and alveoli), and is the malignant tumor with the highest morbidity and mortality. In 2012, there were 1.825 million new cases of lung cancer in the world, accounting for 13.0% of all cancer cases, and 1.590 million lung cancer deaths, accounting for 19.4% of all cancer deaths. Lung cancer was the most common cancer in China in 2015 and the leading cause of cancer-related deaths in China. According to histological lesions, it can be divided into small cell carcinoma (small celllung cancer, SCLC) and non-small cell carcinoma (non-smal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P35/00
CPCA61K36/076A61K36/23A61K36/232A61K36/258A61K36/28A61K36/284A61K36/34A61K36/342A61K36/346A61K36/481A61K36/484A61K36/539A61K36/748A61K36/752A61K36/8888A61K36/8966A61K36/8968A61K36/8994A61K36/904A61K2236/331A61K2236/39A61P35/00A61K2300/00
Inventor 旋静旋菲张文龙丁庆刚李庆杰孙牧
Owner THE AFFILIATED HOSPITAL TO CHANGCHUN UNIV OF CHINESE MEDICINE
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