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Micro-ecology antibacterial preparation for gynecology department and application thereof

A micro-ecology and preparation technology, applied in antifungal agents, antibacterial drugs, medical preparations containing active ingredients, etc., can solve the problems of limited research reports, achieve high bioavailability, increase contact surface, and improve drug efficacy Effect

Pending Publication Date: 2019-07-12
INNER MONGOLIA PUZE BIOLOGICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, there have been many studies abroad on the health-promoting effect of Lactobacillus acidophilus, but domestic research reports in this area are very limited

Method used

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  • Micro-ecology antibacterial preparation for gynecology department and application thereof
  • Micro-ecology antibacterial preparation for gynecology department and application thereof
  • Micro-ecology antibacterial preparation for gynecology department and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1. Lactic acid bacteria antibacterial ability test

[0023] In this experiment, the Oxford cup method was used to test the ability of lactic acid bacteria to inhibit the growth of pathogenic bacteria. Take 240 μL of lactic acid bacteria supernatant and add it to the Oxford cup on the pathogenic bacteria plate prepared in advance. Set up 3 replicates for each strain, add the same amount of sterile water to the control group, put the plate in an incubator at 37 ° C for 48 hours, and cultivate After that, the diameter of the inhibition zone was measured with a vernier caliper.

[0024] Lactic acid bacteria were selected from the common strain bank. As probiotics, the most important feature is to inhibit the growth of pathogenic bacteria. After the antibacterial ability test against Staphylococcus aureus, Escherichia coli and Candida albicans, 4 strains were screened out for their antibacterial ability against pathogenic bacteria Among the stronger isolates, Lac...

Embodiment 2

[0027] Embodiment 2. The comparison of antibacterial activity of compound bacterial agent

[0028] In view of the fact that this product is a gynecological micro-ecological agent, the bifidobacterium V9 and Lactobacillus acidophilus can be screened for research based on the antibacterial ability test data. Three forms of Bifidobacterium, Lactobacillus acidophilus, Bifidobacterium acidophilus and Lactobacillus acidophilus were added to the product, and the antibacterial activity was determined.

[0029] The test operation is as follows:

[0030] (1) Preparation of antibacterial tablets: For liquid antibacterial agents, take sterile and dried filter paper sheets. Add 20 μl of the actual concentration of bacteriostatic agent solution to each piece dropwise, then place the filter paper piece flat on a clean sterile plate, open the cover and dry it in an incubator (37°C), or let it dry naturally at room temperature before use.

[0031] Dissolution antibacterial (antibacterial) pr...

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Abstract

The invention belongs to the field of compound probiotic powder preparations, and particularly relates to a micro-ecology antibacterial preparation for the gynecology department and application thereof. The compound antibacterial preparation is prepared from lactobacillus acidophilus NM and bifidobacterium animalis V9 for formulation optimization, and the unique synergistic effect among cultures is utilized. The micro-ecology antibacterial preparation is high in field planting capability, the immune cell activity can also be enhanced, and the vagina probiotic lactobacillus preparation suitablefor industrial production is developed.

Description

technical field [0001] The invention belongs to the field of compound bacterial powder, and in particular relates to a gynecological microecological antibacterial preparation and application thereof. Background technique [0002] Vaginal inflammation in women caused by Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Candida is the main cause of gynecological diseases. For a long time, sick women were mainly treated with antibiotics. There are few research reports on lactic acid bacteria inhibiting vaginal inflammation in women. [0003] Studies on Lactobacillus acidophilus have shown that using polystyrene as a carrier, Lactobacillus acidophilus can form a biological protective film, which can inhibit the adsorption of 90% of enterococci (Enterococcofaecalis 1131) to polystyrene. Further studies have shown that Lactobacillus acidophilus has a certain ability to adhere to vaginal epithelial cells. After co-cultivating Lactobacillus acidophilus NCFM with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61P15/02A61P31/04A61P31/10A61K35/745
CPCA61K9/0034A61K35/745A61K35/747A61P15/02A61P31/04A61P31/10A61K2300/00
Inventor 闫继彪王潇潇李翠平孙洁宇王东霞
Owner INNER MONGOLIA PUZE BIOLOGICAL PROD CO LTD
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