A kind of pharmaceutical composition for insomnia and preparation method thereof

A composition and drug technology, applied in the field of medical invention, can solve the problems of volatile components, low paeoniflorin content, lack of evidence-based medical evidence, etc.

Active Publication Date: 2021-08-17
贵州大隆药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ma Hong et al. used high-voltage and low-frequency treatment machines made in Japan to treat insomnia caused by neurasthenia. 82 cases were treated, 53 cases were cured, 34 cases were markedly effective, and 20 cases were improved, with a total effective rate of 94%. Although physical therapy has the characteristics of high safety , is getting more and more attention, but it is not widely recognized and applied because of the need for patients to go to medical institutions and the lack of strict evidence-based medical evidence
[0007] (3) Psychotherapy for insomnia seeks to improve sleep by seeking to change maladaptive sleep habits, reduce voluntary or cognitive arousal, change undesirable beliefs and attitudes about sleep, and educate on healthy sleep practices. However, because it needs to be guided by a specific psychiatrist, and the level of curative effect is closely related to the psychiatrist, it has not been widely recognized.
[0018] The above method is not easy to extract the active ingredients of the monarch medicine Jujube Semen, the content of spinosin and jujube saponin A is relatively low; the content of paeoniflorin is also low, and the volatile components are easy to volatilize, which affects the curative effect of the medicine

Method used

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  • A kind of pharmaceutical composition for insomnia and preparation method thereof
  • A kind of pharmaceutical composition for insomnia and preparation method thereof
  • A kind of pharmaceutical composition for insomnia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Prescription: Suanzaoren 110g, Bupleurum 50g, Paeoniae Alba 50g, Silkworm 50g, Albizia Julibrissin 80g, Albizia Julibrissin 80g, Cicada slough 50g, Rush 5g.

[0061] The prescription of embodiment 1 is made by any of the following preparation methods.

[0062] Preparation method one:

[0063] 1) Using CO 2 Supercritical extraction, adding 0.5 times the amount of ethanol with a mass concentration of 75% of medicinal materials as entrainer, extraction pressure of 16MPa, extraction temperature of 38°C, extraction time of 90 minutes, CO2 flow rate of 15L.h -1, extraction and extraction The remaining medicinal residues are ready for use;

[0064] 2) mixing the medicinal dregs extracted in step 1) with Albizia Julibrissinus, Albizia Juliens Bark, Bupleurum Radix, Radix Paeoniae Alba, Rhizoma Rush, Bombyx mori, and cicada slough to obtain a mixture;

[0065]3) Extract the mixture of step 2) twice, the first extraction: add 5 times the amount of water of the mixture, open th...

Embodiment 2

[0084] Prescription: Suanzaoren 700g, Bupleurum 400g, Paeoniae Alba 400g, Silkworm 320g, Albizia Julibrissin 500g, Albizia Julibrissin 500g, Cicada slough 320g, Rush 35g.

[0085] The prescription of embodiment 2 is made by any of the following preparation methods.

[0086] Preparation method one:

[0087] 1) Using CO 2 Supercritical extraction, adding 0.5 times the amount of ethanol with a mass concentration of 75% of medicinal materials as entrainer, extraction pressure of 16MPa, extraction temperature of 38°C, extraction time of 90 minutes, CO2 flow rate of 15L.h -1, extraction and extraction The remaining medicinal residues are ready for use;

[0088] 2) mixing the medicinal dregs extracted in step 1) with Albizia Julibrissinus, Albizia Juliens Bark, Bupleurum Radix, Radix Paeoniae Alba, Rhizoma Rush, Bombyx mori, and cicada slough to obtain a mixture;

[0089] 3) Extract the mixture of step 2) twice, the first extraction: add 5 times the amount of water of the mixture,...

Embodiment 3

[0108] Prescription: Suanzaoren 680g, Bupleurum 390g, Paeoniae Alba 390g, Silkworm 310g, Albizia Julibrissin 490g, Albizia Julibrissin 490g, Cicada slough 310g, Rush 33g.

[0109] The prescription of embodiment 3 is made by any of the following preparation methods.

[0110] Preparation method one:

[0111] 1) Using CO 2 Supercritical extraction, adding 0.5 times the amount of ethanol with a mass concentration of 75% of medicinal materials as entrainer, extraction pressure of 16MPa, extraction temperature of 38°C, extraction time of 90 minutes, CO2 flow rate of 15L.h -1, extraction and extraction The remaining medicinal residues are ready for use;

[0112] 2) mixing the medicinal dregs extracted in step 1) with Albizia Julibrissinus, Albizia Juliens Bark, Bupleurum Radix, Radix Paeoniae Alba, Rhizoma Rush, Bombyx mori, and cicada slough to obtain a mixture;

[0113] 3) Extract the mixture of step 2) twice, the first extraction: add 5 times the amount of water of the mixture,...

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Abstract

The invention relates to a pharmaceutical composition for insomnia and a preparation method thereof. The pharmaceutical composition is prepared from the following medicines in parts by weight: 110-700 parts of Jujube Seed, 50-400 parts of Bupleurum Radix, 50 parts of Radix Paeoniae Alba ‑400 parts, 50‑320 parts of silkworm, 80‑500 parts of Albizia julibrissin, 80‑500 parts of albizia juliensis skin, 50‑320 parts of cicada slough, 5‑35 parts of rush grass, through CO 2 Made by supercritical extraction and water extraction process, the invention has remarkable effect on treating insomnia, which is superior to the prior art.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a pharmaceutical composition for insomnia and a preparation method thereof. Background technique [0002] Insomnia refers to (1) almost only symptoms of insomnia, including difficulty falling asleep, not deep sleep, dreaminess, early awakening, or difficulty in falling asleep after waking up, discomfort after sleeping, fatigue, or daytime sleepiness; (2) Have the predominance of insomnia and pay close attention to the results of insomnia; (3) Dissatisfaction with the quantity and quality of sleep causes obvious distress or impairment of social function; (4) Attacks occur at least 3 times a week and have occurred for at least 1 month; ( 5) Exclude secondary insomnia caused by physical disease or mental disorder symptoms. [0003] At present, there are several methods for the treatment of insomnia, such as chemical drug therapy, physical drug therapy, psychotherapy and Chinese me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61K9/20A61K9/16A61K9/48A61K9/08A61P25/20
CPCA61K9/0095A61K9/1652A61K9/2059A61K9/4866A61K35/64A61K36/233A61K36/48A61K36/65A61K36/71A61K36/725A61K36/88A61K47/36A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61P25/20A61K2300/00
Inventor 刘念宁徐卫东聂开品
Owner 贵州大隆药业有限责任公司
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