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Antibacterial modified graphene oxide and preparation method thereof

A kind of stone oxide, graphene technology, applied in the direction of graphene, single-layer graphene, chemical instruments and methods, etc., can solve the problems of continuous antibacterial, loss, loss of antibacterial properties, etc.

Inactive Publication Date: 2019-07-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Widely used antibacterial agents such as polyhexamethylene guanidine, polyhexamethylene biguanide, gentamicin, penicillin, etc., are easily lost in a humid environment due to their good water solubility. As a result, it loses its antibacterial properties and cannot meet the continuous antibacterial effect

Method used

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  • Antibacterial modified graphene oxide and preparation method thereof
  • Antibacterial modified graphene oxide and preparation method thereof
  • Antibacterial modified graphene oxide and preparation method thereof

Examples

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Effect test

Embodiment 1

[0034] An antibacterial modified graphene oxide, the parts by weight of raw materials are: 0.01 part of graphene oxide, 0.03 part of antibacterial agent, and 50 parts of solvent.

[0035] The antibacterial agent is polyhexamethylene guanidine.

[0036] The preparation method of antibacterial modified graphene oxide comprises the following steps: (1) purification of graphene: Weigh a certain mass of graphene and ultrasonically disperse it in water, and centrifugally wash it three times to obtain purified graphene. (2) Weighing 0.01 part of graphene oxide and ultrasonically dispersing in 50 parts of deionized water for 30 minutes to obtain a uniformly dispersed graphene oxide dispersion. (3) At room temperature, add 0.03 parts of polyhexamethyleneguanidine, stir and ultrasonically stir with a mixer until the dispersion is uniform. (4) Adjust the pH of the solution to 11, and react at 60° C. for 48 hours. (5) The reactant was centrifuged and washed three times, and the product ...

Embodiment 2

[0038] An antibacterial modified graphene oxide, the parts by weight of raw materials are: 0.03 parts of graphene oxide, 0.09 parts of antibacterial agent, and 80 parts of solvent.

[0039] The antibacterial agent is gentamicin.

[0040] The preparation method of antibacterial modified graphene oxide comprises the following steps: (1) purification of graphene: a certain mass of graphene is weighed and ultrasonically dispersed in water, centrifuged and washed three times to obtain purified graphene oxide. (2) Weigh 0.03 parts of graphene oxide and ultrasonically disperse in 80 parts of deionized water for 30 minutes to obtain a uniformly dispersed graphene oxide dispersion. (3) At room temperature, add 0.09 parts of gentamycin, stir and sonicate with a mixer until the dispersion is uniform. (4) Adjust the pH of the solution to 11, and react at 60° C. for 48 hours. (5) The reactant was centrifuged and washed three times, and the product in the lower layer of the centrifuge tub...

Embodiment 3

[0042] An antibacterial modified graphene oxide, the parts by weight of raw materials are: 0.1 part of graphene oxide, 0.3 part of antibacterial agent, and 80 parts of solvent.

[0043] The antibacterial agent is penicillin.

[0044] The preparation method of antibacterial modified graphene oxide comprises the following steps: (1) purification of graphene: Weigh a certain mass of graphene and ultrasonically disperse it in water, and centrifugally wash it three times to obtain purified graphene. (2) Weigh 0.1 part of graphene oxide and ultrasonically disperse in 80 parts of deionized water for 30 min to obtain a uniformly dispersed graphene oxide dispersion. (3) At room temperature, add 0.3 parts of penicillin, stir and sonicate with a mixer until the dispersion is uniform. (4) Adjust the pH of the solution to 11, and react at 60° C. for 48 hours. (5) The reactant was centrifuged and washed three times, and the product in the lower layer of the centrifuge tube was freeze-drie...

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Abstract

The invention discloses an antibacterial modified graphene oxide and a preparation method thereof. The preparation method comprises following steps: weighing a certain amount of graphene oxide, addinga certain amount of water, carrying out dispersing under the assistance of ultrasonic waves for one hour to obtain evenly dispersed graphene oxide water dispersion; weighing a certain amount of polyhexamethylene guanidine hydrochloride, gentamycin, penicillin, kanamycin, and etimicin, adding the components mentioned above into the graphene oxide water dispersion in sequence, stirring the grapheneoxide water dispersion for 1 hour under the assistance of ultrasonic waves, adjusting the pH, carrying out reactions for 48 hours at a temperature of 60 DEG C under mechanical stirring, cooling the reaction product to the room temperature, performing centrifugal washing for three times, placing obtained centrifugal product in a vacuum baking oven with a temperature of 40 DEG C, and drying the centrifugal product in vacuum for 24 hours to obtain the antibacterial modified graphene oxide. The prepared antibacterial modified graphene oxide has the advantages that the equipment requirements are low, the technology is simple, after modification, the antibacterial performance of graphene oxide is largely improved, and the modified graphene oxide has a very good antibacterial performance and biocompatibility and can be used in the fields of biomedicine and antibiosis.

Description

technical field [0001] The invention relates to the field of material application, more specifically, it relates to an antibacterial modified graphene oxide and a preparation method thereof. Background technique [0002] Since graphene was discovered in 2004, due to its good mechanical properties, thermal conductivity, electrical conductivity and biocompatibility, it has been widely studied in the fields of energy, biomedicine and so on. As a derivative of graphene, graphene oxide has a two-dimensional planar structure of graphene and a large number of oxygen-containing functional groups on the surface, such as carboxyl, hydroxyl and epoxy groups, making it more active than graphene. It is easier to chemically modify its surface. [0003] Due to the limitations of the types of antibacterial agents and research on new antibacterial agents, the drug resistance and rapid spread of bacteria made bacterial infections once a potential killer affecting human health. Traditional a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/00A01N47/44A01N43/16A01N43/90A01P1/00C01B32/198
CPCA01N43/16A01N43/90A01N47/44A01N59/00C01B32/198C01B2204/02C01B2204/20
Inventor 夏和生蹇志文陈思尧
Owner SICHUAN UNIV
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