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High performance liquid chromatography method for analyzing benzoyl peroxide in toothpaste

A high-performance liquid chromatography and benzoyl peroxide technology, which is applied to the analysis of materials, material separation, measurement devices, etc., can solve the problem that there is no relevant analysis method for benzoyl peroxide, and achieve reliable and accurate quantitative analysis , The effect of accurate test results

Inactive Publication Date: 2019-06-25
JIANGSU SUPERVISION & INSPECTION INST FOR PROD QUALITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant analytical method for the detection of benzoyl peroxide in the toothpaste matrix in the literature at home and abroad.

Method used

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  • High performance liquid chromatography method for analyzing benzoyl peroxide in toothpaste
  • High performance liquid chromatography method for analyzing benzoyl peroxide in toothpaste
  • High performance liquid chromatography method for analyzing benzoyl peroxide in toothpaste

Examples

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Embodiment 1

[0056] Standard working solution preparation

[0057] Accurately pipette 1.0, 2.0, 4.0, 8.0, 10.0mL of standard stock solution into a 100mL volumetric flask, dilute to the mark with acetonitrile, and shake well. Filter through a 0.45 μm membrane filter for later use. At this time, the concentrations of the standard series solutions are 10.0, 20.0, 40.0, 80.0, 100.0 mg / L.

[0058] Sample preparation

[0059] After the toothpaste sample is squeezed out about 20mm, accurately weigh 1.0000g (accurate to 0.0002g) of a uniform sample into a colorimetric tube (10mL), add 2mL of pure water, shake for 15 minutes, add acetonitrile to dilute to 10mL, and shake well . After standing still, transfer the supernatant to a centrifuge tube, centrifuge at 4000r / min for 10 minutes, take the supernatant and pass it through a 0.45um microporous membrane for sample detection.

[0060] Blank sample preparation:

[0061] Except that no sample was added, the treatment was carried out according to...

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Abstract

The invention discloses a high performance liquid chromatography method for analyzing benzoyl peroxide in toothpaste. The method belongs to the technical field of analysis. The method comprises stepsof separating samples by high performance liquid chromatography; performing a derivatization process on the benzoyl peroxide by online post-column derivatization technology; detecting a blank sample,a sample solution and a standard curve solution by a fluorescence detector, wherein the blank sample, the standard curve, a specimen, the specimen, and the standard curve are successively detected (notice: the number of introductions of the specimen between two standard curves should not exceed 15, and if the number of introductions of the specimen is more than 15, a quality control sample or a standard curve should be added). The method can quickly accurately, and quantitatively analyze the benzoyl peroxide in toothpaste samples, can be used by a market supervision department to monitor the quality of toothpaste products on the market, has accurate detection results and is reliable.

Description

technical field [0001] The invention relates to the technical field of component analysis, in particular to a high performance liquid chromatography analysis method for benzoyl peroxide in toothpaste. Background technique [0002] Benzoyl peroxide is a strong oxidizing agent with a certain bleaching effect. Its chemical alias is also called: dibenzoyl peroxide, and its molecular formula is C 14 h 10 o 4 , the molecular weight is 242.23, and the structural formula is as follows: [0003] [0004] Since benzoyl peroxide has no absorption in the ultraviolet region, it cannot be directly detected with a commonly used ultraviolet detector. The invention utilizes an on-line post-column derivatization combined with a fluorescence detector to detect the benzoyl peroxide in the toothpaste. The national standard GB22115-2008 "Standards for Raw Materials for Toothpaste" has listed benzoyl peroxide as a substance that is prohibited from being added to toothpaste. There is no rel...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/74
Inventor 薛彦军苏玉倩孙牧范琪肖苏熠
Owner JIANGSU SUPERVISION & INSPECTION INST FOR PROD QUALITY
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