Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Artemisinin separation and purification technology

A technology for separation and purification of artemisinin, which is applied in organic chemistry and other fields, can solve the problems of time-consuming process, affecting experimental efficiency, low yield of artemisinin, etc., and achieve the effect of reducing safety risks and simplifying the process

Active Publication Date: 2019-06-25
HUNAN HEALTHWARE BIOTECH LTD
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method saves energy and reduces consumption, and solves the problem that artemisinin is thermally decomposed during the extraction process and affects the yield. However, the process takes a long time, such as each crystallization takes more than 15 hours, which seriously affects the experimental efficiency; and the use of Silica gel column for purification, so that the yield of artemisinin is low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A process for separating and purifying artemisinin, comprising the following steps:

[0041] S1. Concentrate the artemisinin petroleum ether extract to 1 / 40 of the original volume under normal pressure and a temperature of 50°C, then naturally cool down to 25°C while stirring, continue to keep warm and stir for 1 hour, and press filter to obtain artemisinin Coarse crystal 1, mother liquor 1, the mother liquor 1 is concentrated to dryness under reduced pressure to obtain artemisinin extract 1, wherein the content of artemisinin in the artemisinin petroleum ether extract is 0.15%;

[0042] S2. Add the artemisinin extract 1 into the alcoholic aqueous solution and heat to 25°C, stir to dissolve for 1 hour, then cool down to 15°C, and press filter to obtain the alcoholic water extract 1 and the artemisinin extract 2, wherein, The alcoholic aqueous solution is a methanol solution with a volume fraction of 10%, and the mass-volume ratio of artemisinin extract 1 to the alcoholi...

Embodiment 2

[0050] A kind of artemisinin separation and purification process, its difference with embodiment 1 is,

[0051] The alcoholic solvent described in step S5 is ethanol.

[0052] In this example, the yield of fine artemisinin was 69%, the purity was 96.4%, and the single impurity was not more than 1%.

Embodiment 3

[0054] A process for separating and purifying artemisinin, comprising the following steps:

[0055] S1. Concentrate the artemisinin petroleum ether extract to 1 / 50 of the original volume under normal pressure and a temperature of 70°C, then naturally cool down to 25°C while stirring, continue to keep warm and stir for 1 hour, and press filter to obtain artemisinin Coarse crystal 1, mother liquor 1, the mother liquor 1 is concentrated to dryness under reduced pressure to obtain artemisinin extract 1, wherein the content of artemisinin in the artemisinin petroleum ether extract is 0.5%;

[0056] S2. Add the artemisinin extract 1 into the alcoholic aqueous solution and heat to 25°C, stir to dissolve for 1 hour, then cool down to 40°C, and centrifuge to obtain the alcoholic water extract 1 and the artemisinin extract 2, wherein, The alcohol aqueous solution is a tert-butanol solution with a volume fraction of 10%, and the mass volume ratio of artemisinin extract 1 to the alcohol a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of separation and purification of artemisinin, and concretely relates to an artemisinin separation and purification technology. The separation and purification technology comprises the following steps: S1, Sweet Wormwood Herb extract is concentrated, and undergoes press filtration to obtain first crude artemisinin crystals and a first mother liquor, thefirst mother liquor is concentrated under a reduced pressure to obtain a first artemisinin extract; S2, the first artemisinin extract is added to an alcohol-water solution, stirring is performed fordissolving and dispersing, and then separation is carried out to obtain a first alcohol-water extract and a second artemisinin extract; S3, the second artemisinin extract undergoes processes in step S2 to obtain a second alcohol-water extract and a third artemisinin extract; S4, the first alcohol-water extract and the second alcohol-water extract are mixed, and the obtained mixture is cooled and crystallized, and then undergo press filtration to obtain second crude artemisinin crystals and a second mother liquor; and S5, the first crude artemisinin crystals and the second crude artemisinin crystals are mixed, and are dissolved in an alcohol solvent, the obtained solution is filtered, and the obtained filtrate is heated, and then undergoes reduced pressure concentration, cooling, press filtration and drying to obtain refined artemisinin. The product obtained by the separation and purification technology has the advantages of high recovery rate, high purity and high crystal form quality.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of artemisinin, and in particular relates to a separation and purification process of artemisinin. Background technique [0002] Artemisinin, also known as artemisinin, is a sesquiterpene lactone compound with a peroxy bridge extracted and isolated from the leaves of Artemisia annua of Compositae plant in 1971 by Chinese pharmaceutical workers. The preparation techniques of artemisinin mainly include plant extraction, biosynthesis, chemical synthesis and plant tissue culture. Directly extracting artemisinin from Artemisia annua can extract its active ingredients according to the solubility difference of various components in different solvents in Chinese herbal medicine. How to extract artemisinin more efficiently and ensure the purity of the product while reducing the energy loss in the extraction process is a technical problem to be solved in this field. [0003] After sear...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/20
CPCC07D493/20C07D493/18
Inventor 张梅赵金召赵金全
Owner HUNAN HEALTHWARE BIOTECH LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com