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A kind of organic/inorganic combined antibacterial composition and its preparation method and application

The technology of an antibacterial composition and an inorganic antibacterial agent is applied in the field of organic/inorganic combined antibacterial composition and its preparation, and can solve the problems of in vivo degradation residue, failure to reach effective blood drug concentration, poor sustained release effect and the like

Active Publication Date: 2020-10-23
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the traditional systemic injection of antibiotics often fails to reach the effective blood concentration in the local area of ​​infection, and the therapeutic effect is not ideal. Moreover, due to the abuse of antibiotics, many infectious pathogens have multiple cross-drug resistance. The combination of antibiotics can only be used in Reduce the occurrence of drug resistance to a certain extent
In addition, organic drug stents have the problems of poor slow-release effect and residual degradation in vivo, which are difficult to meet clinical needs

Method used

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  • A kind of organic/inorganic combined antibacterial composition and its preparation method and application
  • A kind of organic/inorganic combined antibacterial composition and its preparation method and application
  • A kind of organic/inorganic combined antibacterial composition and its preparation method and application

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Embodiment 1

[0035] This embodiment provides an organic / inorganic combined antibacterial composition and a preparation method thereof.

[0036] In the organic / inorganic combined antibacterial composition, the mass ratio of nano copper, tigecycline and polydopamine is 4:1:4.

[0037] The preparation method includes the following steps:

[0038] (1) Dissolve 0.1g chitosan, 1ml acetic acid and 0.5g citric acid in 130ml distilled water, stir magnetically for 10min, transfer to a 50ml polytetrafluoroethylene lined autoclave, react at 180℃ for 6h, after the reaction is complete The autoclave was cooled to room temperature, and the resulting reaction liquid was carbon dot citrate.

[0039] (2) Dissolve 20ml of 0.1mol / L copper chloride, 20ml of citric acid carbon point, 40g of sodium hydroxide and 6.2ml of 35% hydrazine hydrate solution in 40ml of distilled water, stir and react at 70℃ for 12h, and precipitate the resultant After being washed with distilled water and absolute ethanol, freeze-dried at -80...

Embodiment 2

[0042] This embodiment provides an organic / inorganic combined antibacterial composition and a preparation method thereof.

[0043] In the organic / inorganic combined antibacterial composition, the mass ratio of nano copper, tigecycline and polydopamine is 2:1:4.

[0044] The preparation method includes the following steps:

[0045] (1) Dissolve 0.2g chitosan, 1.5ml acetic acid and 0.5g citric acid in 130ml distilled water, stir magnetically for 10min, transfer to a 50ml polytetrafluoroethylene lined autoclave, react at 180℃ for 6h, the reaction is complete Then the autoclave was cooled to room temperature, and the resulting reaction liquid was citrate carbon dots.

[0046] (2) Dissolve 20ml of 0.1mol / L copper chloride, 20ml of citric acid carbon point, 80g of sodium hydroxide, 6.2ml of 35% hydrazine hydrate solution in 40ml of distilled water, stir and react at 70℃ for 18h, and then precipitate the resultant After being washed with distilled water and absolute ethanol, freeze-dried at...

Embodiment 3

[0049] This embodiment provides an organic / inorganic combined antibacterial composition and a preparation method thereof.

[0050] In the organic / inorganic combined antibacterial composition, the mass ratio of nanometer copper, tigecycline and polydopamine is 4:3:8.

[0051] The preparation method includes the following steps:

[0052] (1) Dissolve 0.4g chitosan, 2ml acetic acid and 2g citric acid in 130ml distilled water, stir magnetically for 10min, transfer to a 50ml polytetrafluoroethylene lined autoclave, react at 180℃ for 6h, after the reaction is complete The autoclave was cooled to room temperature, and the resulting reaction liquid was carbon dot citrate.

[0053] (2) Dissolve 20ml of 0.1mol / L copper chloride, 20ml of citric acid carbon point, 160g of sodium hydroxide, 6.2ml of 35% hydrazine hydrate solution in 40ml of distilled water, stir and react at 70°C for 24h, and precipitate the resultant After washing with distilled water and absolute ethanol, freeze-dried at -80°C ...

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Abstract

The invention belongs to the technical field of medical materials and particularly relates to an organic / inorganic combined antibacterial composition and a preparation method and application thereof.The organic / inorganic combined antibacterial composition comprises nano-copper, tigecycline and polydopamine; the compound of inorganic antibacterial agent nanometer copper and organic antibiotic tigecycline is wrapped by polydopamine to produce the produce. The results show that the product has good resistance to multi-drug resistant bacteria and is attached to the surface of a catheter after air drying and filming, slow release of the antibacterial agent is achieved, and technical shortcomings that single antibactic has poor antibacterial effect, low antibacterial duration and easy sheddingof spraying composite films.

Description

Technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an organic / inorganic combined antibacterial composition and a preparation method and application thereof. Background technique [0002] In clinical operations, complications caused by catheter-related infections are a very difficult problem. The original material made of catheters does not have antibacterial properties, and pathogenic microorganisms can easily adhere to the surface of the material to grow, often causing local or Systemic infection. At present, a large number of antibiotics are mainly used clinically to reduce the occurrence of catheter-related infections. However, the traditional systemic antibiotic injection therapy often fails to reach the effective blood concentration in the infected area, and the therapeutic effect is not ideal, and because of the abuse of antibiotics, many infectious pathogens have multiple cross-resistance. The combination...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K33/34A61P31/04A61L29/16A61L29/08A61L29/10A61K31/65
Inventor 蒋刚彪吴夏晓张宇周初松刘永林胡甜李曾林陈文照
Owner SOUTH CHINA AGRI UNIV
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