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Traditional Chinese medicine composition used for treating primary myelofibrosis and preparation method and application thereof

A technology for myelofibrosis and a composition is applied in the field of traditional Chinese medicine compositions for treating primary myelofibrosis and the field of preparation thereof, which can solve the problems of lack of definite drugs, lack of myelofibrosis, and difficulty in guaranteeing curative effects, and achieves hard relapse. , Good therapeutic effect, no toxic side effects

Inactive Publication Date: 2019-05-31
苏凤哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are no effective measures for the treatment of primary myelofibrosis. Corresponding measures are given according to the degree of myelofibrosis tissue proliferation and clinical manifestations. The main purpose of treatment is to improve hematopoietic function, correct anemia, bleeding, and relieve splenomegaly. Most of the compressive symptoms caused by the disease are symptomatic and supportive treatments. There are almost no definite drugs for inhibiting the formation of myelofibrosis and preventing its development, and long-term medication is difficult to guarantee the curative effect, but the side effects are great

Method used

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  • Traditional Chinese medicine composition used for treating primary myelofibrosis and preparation method and application thereof
  • Traditional Chinese medicine composition used for treating primary myelofibrosis and preparation method and application thereof
  • Traditional Chinese medicine composition used for treating primary myelofibrosis and preparation method and application thereof

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Effect test

Embodiment 1

[0017] Take 12g of Eclipta, 12g of Cuscuta, 20g of Five-clawed Dragon, 15g of August Zha, 12g of Curcuma, 15g of Shijianchuan, 15g of Chuanposhi, 15g of Nightshade Solanum, 3g of Scorpio, 3g of Panax notoginseng powder (chong), Add 600mL of water, then decoct for 30min, decoct until about 200mL of the medicinal liquid remains, and filter out the medicinal liquid; add 400mL of water to the medicinal dregs, decoct for 20min, decoct until the remaining 200mL of the medicinal liquid, and filter out the medicinal liquid; It is obtained after the liquid medicine is combined. Appropriate pharmaceutical excipients are added to the obtained medicinal liquid, and a decoction is prepared according to a conventional process.

[0018] After the liquid medicine is obtained, according to the needs of different preparations, suitable pharmaceutical excipients can be added to the obtained liquid medicine, and according to the conventional preparation process, it can be made into tablets, capsu...

Embodiment 2

[0033] Patient Zhang Moumou, male, 67 years old, from Tongzhou District, Beijing, was admitted to the hospital on April 22, 2016 because of abdominal distension and fatigue for one year, which aggravated for one week.

[0034] History of present illness: The patient developed fatigue a year ago due to obvious incentives, distending pain in both hypochondriacs intermittently, palpitations, shortness of breath, occasional night sweats, and no bleeding tendency after activities. L, RBC 2.05×1012 / L, Hb 65g / L, PLT 132×109 / L. B-ultrasound showed: giant spleen. Bone marrow puncture smear shows: bone marrow hyperplasia is obviously active, hyperplasia of granular, red and giant three lines of bone marrow: bone marrow pathology prompts: hyperplasia of three lines of granular, red and giant, reticulin fibers (+++). The BCR / ABL fusion gene was negative, the JAK2V617F gene was positive, the MPLW515 and CALR genes were both negative, and the karyotype analysis was 46XY. The diagnosis was...

Embodiment 3

[0041] Patient Liu Moumou, male, 59 years old, from Chaoyang District, Beijing, was admitted to the hospital for treatment on April 22, 2017 due to dizziness and fatigue for 6 months.

[0042] History of present illness: The patient developed dizziness and fatigue symptoms without obvious incentives six months ago. He went to the local hospital. The blood test showed: white blood cells 3.5×109 / L, hemoglobin 92g / L, red blood cells 2.8×1012 / L, platelets 110×109 / L. Bone marrow biopsy at the Tianjin Institute of Blood Diseases showed: extensive proliferation of bone marrow fibrous tissue, decreased hematopoietic cells, no significant abnormalities in the ratio of granulosa to red at each stage, many megakaryocytes, large cell bodies, and occasional eosinophils, considering primary disease Myelofibrosis. B-ultrasound showed: (1) mild fatty liver; (2) spleen thickness 7.6cm, splenomegaly degree II. Outpatient admission with primary myelofibrosis.

[0043] Past medical history: p...

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Abstract

The invention discloses a traditional Chinese medicine composition used for treating primary myelofibrosis. The traditional Chinese medicine composition comprises esliptae herba, the seeds of Chinesedodder, humulus scandens, fiveleaf akebia fruits, radix curcumae, Chinese sage herb, radix cudramiae, black nightshade herb, scorpio and pseudo-ginseng powder. The invention further provides a preparation method and application of the traditional Chinese medicine composition used for treating the primary myelofibrosis. According to the traditional Chinese medicine composition used for treating theprimary myelofibrosis, all traditional Chinese medicine materials mutually cooperate and act together according to the main, adjuvant, assistant and conductant compatibility so as to act on a focus and give play to the treatment effect on the primary myelofibrosis. Through clinical tests, it is shown that the traditional Chinese medicine composition has a good treatment effect on the primary myelofibrosis, the total effective rate reaches 80%, after being cured, the primary myelofibrosis is not prone to recurrence, and the traditional Chinese medicine composition is free of side and toxic effects and high in application value.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating primary myelofibrosis, a preparation method and application thereof. Background technique [0002] Primary myelofibrosis is a myeloproliferative disease caused by collagen hyperplasia in bone marrow hematopoietic tissue, and its fibrous tissue seriously affects hematopoietic function. The incidence rate of the disease is 0.2-2 / 100,000, and the age of onset is mostly between 50-70. Males are slightly higher than females. The etiology is not clear, and it may be related to abnormal hematopoietic stem cells. The disease presents different degrees of bone marrow fibrous tissue Hyperplasia, and extramedullary hematopoiesis mainly in the spleen, followed by liver and lymph nodes, the typical clinical manifestations are red blood cells and myelocytic anemia, and there are more teardrop-shaped red blood cells,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P19/08A61P7/00A61K35/646
Inventor 苏凤哲苏博洋
Owner 苏凤哲
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