Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dendrobium officinale kimuraet migo extract rich in flavone carbon glycosides and application of extract

A technology of Dendrobium officinale and flavonoid carbon glycosides, applied in the field of medicine, can solve the problems of rare reports on the activity of crude polysaccharide components, and achieve the effects of promoting comprehensive utilization and development, expanding the scope of application, and improving metabolic disorders.

Active Publication Date: 2019-05-31
ZHEJIANG CHINESE MEDICAL UNIVERSITY
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have reported that the polysaccharides of Dendrobium candidum have related effects such as enhancing immunity, lowering blood sugar, lowering blood pressure, and anti-oxidation, but there are few reports on the activities of ingredients other than crude polysaccharides.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dendrobium officinale kimuraet migo extract rich in flavone carbon glycosides and application of extract
  • Dendrobium officinale kimuraet migo extract rich in flavone carbon glycosides and application of extract
  • Dendrobium officinale kimuraet migo extract rich in flavone carbon glycosides and application of extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Raw material selection: choose Dendrobium candidum as raw material, dry and pulverize it for later use.

[0025] (2) Reflux extraction: Add the raw materials into an ethanol aqueous solution with a volume concentration of 80%, put them into a decoction machine, wherein the mass volume fraction of the medicinal materials is 50g / mL; reflux extraction once, 3.0h each time, and filter;

[0026] (3) The combined filtrates are concentrated under reduced pressure: the concentration temperature is 55°C, the vacuum degree is -0.07~-0.09Mpa, the concentrated solution has no alcohol smell, and the crude extract is obtained;

[0027] (4) Use petroleum ether and water-saturated n-butanol to extract the crude extract successively, select the n-butanol part, concentrate under reduced pressure (concentration temperature 60° C.) to remove n-butanol, and obtain apigenin-containing aglycone after drying flavonoid glycosides extract.

Embodiment 2

[0029] (1) Raw material selection: the medicinal dregs extracted from Dendrobium officinale were selected as raw materials, dried and pulverized for later use.

[0030] (2) Reflux extraction: Add the raw materials into absolute ethanol, put them into a decoction machine, wherein the mass volume fraction of the medicinal materials is 125g / mL; reflux extraction 4 times, each time for 0.5h, and filter;

[0031] (3) The combined filtrates are concentrated under reduced pressure: the concentration temperature is 50°C, the vacuum degree is -0.07~-0.09Mpa, the concentrated solution has no alcohol smell, and the crude extract is obtained;

[0032] (4) Use petroleum ether and ethyl acetate to extract the crude extract successively, select the ethyl acetate part, concentrate under reduced pressure (concentration temperature 60°C) to remove the selected ethyl acetate, and obtain the aglycon containing apigenin after drying Flavonoid glycosides extract.

Embodiment 3

[0034] (1) Raw material selection: the medicinal dregs extracted from Dendrobium officinale were selected as raw materials, dried and pulverized for later use.

[0035](2) Reflux extraction: Add the raw materials into an ethanol aqueous solution with a volume concentration of 60%, put them into a decoction machine, wherein the mass volume fraction of the medicinal materials is 55g / mL; reflux extraction 3 times, each time for 1h, and filter;

[0036] (3) Concentrate the combined filtrate under reduced pressure: the concentration temperature is 65°C, the vacuum degree is -0.07~-0.09Mpa, the concentrated solution has no alcohol smell, and the crude extract is obtained;

[0037] (4) Adopt polyamide column chromatography, use pure water, 20% ethanol, 70% ethanol to elute successively, collect 70% eluate, concentrate under reduced pressure (concentration temperature is 55 ℃, vacuum degree is-0.07~-0.09Mpa ), until there is no alcohol taste, and after drying, the flavonoid carbon gly...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Mass volume fractionaaaaaaaaaa
Mass volume fractionaaaaaaaaaa
Login to View More

Abstract

The invention discloses a dendrobium officinale kimuraet migo extract rich in flavone carbon glycosides and application of the extract. The extract is prepared by taking dendrobium officinale kimuraetmigo or a water extraction residue thereof as a raw material and performing drying, crushing, reflux extraction, separation, purification and drying, wherein the total flavone content of the extractis 2.5-80%, and the extract contains flavone carbon glycoside components with apigenin as aglycone. It is proved by experiments that the dendrobium officinale kimuraet migo extract has the advantagesof comprehensively alleviating various metabolic disorders, lowering blood pressure, reducing blood sugar, regulating blood fat, improving microcirculation, reducing blood viscosity and the like. After being processed by means of a modern preparation technology, the extract can be applied to drugs, healthcare food or formulated food for special medical use and the like with the effects of preventing and treating metabolism-related diseases such as hypertension, hyperlipemia and diabetes.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an extract of dendrobium officinale rich in flavonoid carbon glycosides and an application thereof. Background technique [0002] With the changes in modern human diet structure, living habits, environment, and rhythm of life, metabolic-related diseases such as diabetes, hyperlipidemia, hypertension, and hyperuricemia have a high incidence and are showing a younger trend. The above-mentioned metabolic-related diseases are high-risk factors for cardiovascular and cerebrovascular diseases, and the above-mentioned risk factors often affect each other, and multiple abnormalities appear in the same individual at the same time. According to research, when multiple metabolic disorders co-occur, the incidence of cardio-cerebral-kidney complications and peripheral vascular disease increases significantly, seriously endangering the health of patients. Faced with the phenomeno...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8984A61P3/00A61P3/06A61P3/10A61P5/50A61P9/12A23L33/105
Inventor 颜美秋吕圭源陈素红苏洁俞静静楼招欢
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com