Biological activity ceramic bracket with heterogeneous porous bionic natural bone structure and preparation method of biological activity ceramic bracket

Abstract

The invention discloses a biological activity ceramic bracket with a heterogeneous porous bionic natural bone structure and a preparation method of the biological activity ceramic bracket. According to the preparation method of the biological activity ceramic bracket, biological activity ceramic slurry is directly printed and molded by virtue of an advanced direct extrusion molding technology, a porous structure of continuous changing from external compactness to internal loose is established, and bionics of the natural bone structure is realized. The preparation method of the biological activity ceramic bracket comprises the following steps of (1) preparation of biological activity ceramic powder for 3D printing, (2) preparation of the biological activity ceramic slurry, (3) printing of the biological activity ceramic bracket with the heterogeneous porous bionic natural bone structure, and (4) drying and sintering of the bracket, and the biological activity ceramic bracket with the heterogeneous porous bionic natural bone structure is obtained. According to the biological activity ceramic bracket with the heterogeneous porous bionic natural bone structure and the preparation method of the biological activity ceramic bracket, the self-regulating biological activity ceramic powder special for 3D printing is adopted, the advantage of 3D printing technology is combined, accurate control of gradient pore size of the ceramic bracket is realized, the problem of heterogeneous structure accurate establishment is solved, and great significance is achieved for regeneration and repairof bone defects.

Description

technical field [0001] The invention relates to the field of 3D printing, in particular to a bioactive ceramic support with a heterogeneous porous bionic natural bone structure and a preparation method thereof. Background technique [0002] Trauma, disease, and the aging of the population in recent years have led to an increasing number of patients with bone defects. The development of bone tissue engineering provides a new method for clinical bone defect treatment. Calcium phosphate ceramics have become the most potential artificial bone substitute materials because of their similar chemical composition and crystal structure to the inorganic minerals in natural bone. In addition to chemical composition, a good scaffold for bone tissue engineering should also mimic the structure of natural bone. Natural bone consists of dense cortical bone on the outside and cancellous bone that is loose and porous on the inside. Bone compact is composed of multiple layers of closely arra...

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Problems solved by technology

In the late sintering process, residual stress will be formed at the gradient layer, which makes it easy to form fractures at the interface of the gradient layer when the bracket is implanted into the load-bearing part; (2) Tang, et al tried to use centrifugal casting combined with directional freezing casting technology to make the slurry The aluminum oxide particles in the mold move from the center to the periphery of the mold under the action of centrifugal force, and finally obtain a heterogeneous porous structure with a stable gradient distribution due to the ceramic viscosity and the electrostatic repulsion of the particles themselves (Tang, Yufei, Cong Wu, and Kang Zhao .Ceramics International (2017); In summary, it can be found that there are three problems in the use of these traditional preparation processes: (1) the pore size of the heterogeneous porous structure cannot be precisely controlled; (2) the connectivity of the pores cannot be guaranteed; ( 3) Fractures are prone to occur at the interface of the gradient layer, which greatly reduces the yield of fired products

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