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Drug continuous granulation method

A technology of medicine and production method, which is applied in the field of continuous granulation of medicine, can solve the problems of difficult enlargement, low efficiency, and high energy consumption of spray drying granulation, and achieve the goal of enhancing cohesive force, improving production efficiency, and improving product quality Effect

Inactive Publication Date: 2019-05-21
苏州璞佩珊科技有限公司
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Problems solved by technology

However, the above-mentioned technologies have some disadvantages. For example, high-speed shear mixing granulation is a batch process, resulting in low efficiency and difficulty in scaling up. Fluidized bed granulation is prone to pollution and consumes a lot of energy. Spray drying granulation consumes a lot of energy and involves Handling of solvents (generated ambient pressure)

Method used

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  • Drug continuous granulation method
  • Drug continuous granulation method
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Embodiment Construction

[0027] The present invention will be described in detail below in conjunction with the accompanying drawings and specific implementation examples, but the embodiments of the present invention are not limited thereto.

[0028] see figure 1 and figure 2 As shown, the continuous granulation production process of the drug is as follows:

[0029] Step 1: Start the reciprocating single-screw extruder, set the speed of the extruder to 100 rpm, and set the barrel temperature in each zone of the extruder to 40 degrees Celsius (the first zone is not heated);

[0030] Step 2: according to the pharmaceutical formula, theophylline of 30% of the active substance of the drug, the polyvinylpyrrolidone of 2.5% of the solid binder, the lactose (filler) of the auxiliary material 58% and the magnesium stearate of the lubricant of 0.5% (prepared with lactose Pre-mixed together) 1, 2 and 3 are quantitatively and continuously added to the barrel of the first zone of the reciprocating single-screw...

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Abstract

The invention provides a drug continuous granulation method, which prepares granulated drugs by continuously adding drug active ingredients, excipients, a binder and other additives into a mixing device and uniformly mixing all the materials; wherein the mixing device adopts a reciprocating single-screw extruder which comprises a screw rotating in the circumferential direction and reciprocating inthe axial direction; a fixed machine barrel is arranged outside the screw and provided with an independent temperature control system; and openings are formed in the machine barrel for feeding the materials and injecting liquids according to the requirements of the process.

Description

technical field [0001] The invention relates to medicine granulation technology, in particular to a method for continuous medicine granulation. Background technique [0002] Drug granulation is the operation of processing drug formulations in the state of powder, molten liquid, aqueous solution, etc. into granules of a certain shape and size. [0003] The purpose of drug granulation: to improve fluidity, facilitate packaging and tabletting; prevent segregation of various components due to particle size and density differences; prevent dust flying and adhesion on the wall of the device; adjust bulk density to improve solubility; Uniformity of pressure transmission in drug production; easy to take, easy to carry, and increase commodity value. [0004] Currently widely used drug granulation techniques include high-speed shear mixing granulation, fluidized bed granulation and spray drying granulation. However, the above-mentioned technologies have some disadvantages. For examp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J2/20
Inventor 杨高品
Owner 苏州璞佩珊科技有限公司
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