A kind of porous hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and distilled water, which is applied in the field of porous hemostatic sponge and its preparation, can solve the problems of slow hemostasis, low safety, non-degradable or complete degradation, etc., and achieve the promotion of healing, high antibacterial and bacteriostatic rate, plasticity and modification strong effect

Inactive Publication Date: 2020-06-16
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a porous hemostatic sponge and its preparation method to solve the problems of slow hemostatic speed, non-degradable or complete degradation and low safety of existing hemostatic materials

Method used

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  • A kind of porous hemostatic sponge and preparation method thereof
  • A kind of porous hemostatic sponge and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032] The porous hemostatic sponge of the present embodiment comprises: by mass percentage, 2.20% polyglutamic acid, 0.72% lysine, 0.72% polylysine, 0.72% casein, 4.42% calcium chloride, 0.72% of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.72% of N-hydroxysuccinimide, and the balance is distilled water.

[0033] Each raw material component was weighed according to the above ratio for use in preparing a porous hemostatic sponge.

[0034] The preparation method of the porous hemostatic sponge of the present embodiment comprises:

[0035] (1) dissolving calcium chloride in distilled water, then adding polyglutamic acid, mixing and heating at a temperature of 35° C. to obtain the first liquid;

[0036] (2) Mix lysine and polylysine in distilled water, add casein after dissolving, then heat at 30°C and stir at a speed of 2000r / min for 20min to obtain the second liquid;

[0037](3) Add the first liquid to the second liquid, mix well and add 1-(3-dimethylaminopr...

Embodiment 2

[0040] The porous hemostatic sponge of the present embodiment comprises: by mass percentage, 7.08% polyglutamic acid, 5.31% lysine, 5.31% polylysine, 5.31% casein, 0.80% calcium chloride, 5.31% of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 5.31% of N-hydroxysuccinimide, the balance being distilled water.

[0041] Each raw material component was weighed according to the above ratio for use in preparing a porous hemostatic sponge.

[0042] The preparation method of the porous hemostatic sponge of the present embodiment comprises:

[0043] (1) dissolving calcium chloride in distilled water, adding polyglutamic acid, mixing and heating at a temperature of 35°C-60°C to obtain the first liquid;

[0044] (2) Mix lysine and polylysine in distilled water, add casein after dissolving, then heat at 40°C and stir at a speed of 1001r / min for 5min to obtain the second liquid;

[0045] (3) Add the first liquid to the second liquid, mix well and add 1-(3-dimethylaminopropy...

Embodiment 3

[0048] The porous hemostatic sponge of the present embodiment comprises: by mass percentage, 3.10% polyglutamic acid, 1.24% lysine, 2.07% polylysine, 0.80% casein, 1.70% calcium chloride, 2.07% of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 2.07% of N-hydroxysuccinimide, and the balance is distilled water.

[0049] Each raw material component was weighed according to the above ratio for use in preparing a porous hemostatic sponge.

[0050] The preparation method of the porous hemostatic sponge of the present embodiment comprises:

[0051] (1) dissolving calcium chloride in distilled water and then adding polyglutamic acid to mix and heat at 40°C to obtain the first liquid;

[0052] (2) Mix lysine and polylysine in distilled water, add casein after dissolving, then heat at 32°C and stir at a speed of 1100r / min for 10min to obtain the second liquid;

[0053] (3) Add the first liquid to the second liquid, mix well and add 1-(3-dimethylaminopropyl)-3-ethylcarbod...

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Abstract

The invention discloses a porous hemostatic sponge and a preparation method thereof, belonging to the technical field of biological materials. The porous hemostatic sponge of the present invention comprises: by mass percentage, 2.20% to 7.08% polyglutamic acid, 0.72% to 5.31% lysine, 0.72% to 5.31% polylysine, 0.72% to 5.31% Casein, 0-4.42% calcium chloride, 0.72%-5.31% 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.72%-5.31% N ‑Hydroxysuccinimide, balance distilled water. The porous hemostatic sponge of the present invention has high porosity, can be degraded and absorbed, can be antibacterial, bacteriostatic, and promotes healing, has a strong liquid absorption rate, and is a porous hemostatic sponge that can quickly and effectively stop bleeding.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a porous hemostatic sponge and a preparation method thereof. Background technique [0002] Blood is one of the important components of the human body, accounting for about 8% of an adult's body weight, which is equivalent to 70-80 milliliters of blood per kilogram of body weight, and an adult (about 70kg) has about 5L of blood. It is responsible for the material exchange of all tissues and organs of the human body. If a person loses more than 30% of the total blood in a short period of time, he will die due to excessive blood loss. In traffic accidents, natural disasters, wars and other fatal events, most of them are caused by uncontrollable hemorrhage. Therefore, effective hemostasis plays a very important role in saving the lives of patients. To achieve effective hemostasis, the application of hemostatic materials is inseparable. It can be seen that it is imminen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/00A61L24/00A61L24/04
Inventor 汪建新魏冉陈太军王莹莹冯波翁杰段可
Owner SOUTHWEST JIAOTONG UNIV
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