Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of recombinant human keratinocyte growth factor

A technology of keratinocytes and growth factors, which is applied in the field of medicine, can solve the problems of patients with serious illnesses, multiple treatment costs, interruption of treatment plans, etc., and achieve the effect of relieving pain, saving treatment costs, and ensuring treatment plans

Active Publication Date: 2019-05-07
江苏奥赛康生物医药有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The occurrence of the above-mentioned mucosal injury will lead to an increase in the length of hospitalization and readmission rate, and lead to the interruption or early termination of the treatment plan, and also bring greater pain and more treatment costs to the patient
However, there is no research report on the use of rhKGF-1 in the repair of intestinal mucosal damage caused by radiotherapy and chemotherapy.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of recombinant human keratinocyte growth factor
  • Application of recombinant human keratinocyte growth factor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Preparation of the pharmaceutical composition containing recombinant human keratinocyte growth factor-1

[0024] Weigh recombinant human keratinocyte growth factor-1, mannitol, sucrose, L-histidine, and Tween 20 according to the mass ratio of 1:8:4:0.37:0.021. First, recombinant human keratinocyte growth factor- 1 for purification, exchange the obtained feed liquid into a solution containing sucrose, L-histidine and mannitol, adjust the concentration to the target value, then add Tween 20, finally adjust the pH to 6.5 with HCl, and obtain A pharmaceutical composition containing recombinant human keratinocyte growth factor-1. The pharmaceutical composition is represented by ASK. Animal experiments were further carried out to verify the role and effect of recombinant human keratinocyte growth factor-1 in repairing small intestinal mucosal injury and colonic mucosal injury.

Embodiment 2

[0025] Example 2 Test on the repair of mucosal damage in NOD / SCID mice with leukemia caused by combined chemotherapy regimens

[0026] (1) Experimental drugs, animals, cell lines, reagents and instruments

[0027] Test drug:

[0028] (1) Test drug (ASK), specification: 6.25mg / bottle, batch number: 20160202.

[0029] (2) Palifermin (Palifermin), specification: 6.25mg / bottle, batch number: 929594, American AMGEN company.

[0030] (3) Cytarabine, lot number: 54G507, Actavis Italy S.p.A company.

[0031] (4) Etoposide, batch number: B11C1607004, Qilu Pharmaceutical Co., Ltd.

[0032] (5) Daunorubicin, batch number: 15045411, Hisun Pfizer Pharmaceutical Co., Ltd.

[0033] Test animals:

[0034] SPF grade NOD / SCID mice, weighing 15-20g, 90, male and female, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal use license number SYXK (E) 2014-0013, animal license number No. 11400700181196, No. 11400700181197.

[0035] Test cell line:

[0036] HL-60 human pro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a recombinant human keratinocyte growth factor-1 or a pharmaceutical composition containing the recombinant human keratinocyte growth factor-1. The recombinant human keratinocyte growth factor-1 is used for an application for preparing a medicine for repairing intestinal mucosal injury. The clinical application can control increase of hospitalization period and readmission rate caused by the mucosal injury during tumor treatment, at the same time can also ensure continuity of a treatment scheme, and can also reduce pains and save treatment cost for patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of recombinant human keratinocyte growth factor-1. Background technique [0002] The main treatments for cancer today include radiation therapy (often referred to as radiotherapy), chemotherapeutic drugs (often referred to as chemotherapy), and surgery. Among them, surgical therapy is more suitable for non-metastatic solid tumors, and combined radiotherapy and chemotherapy are needed for advanced tumors. However, due to the lack of selectivity of radiotherapy and chemotherapy, they can also kill normal tissue cells while killing tumor tissues, so there are serious adverse reactions, which make patients weaker and reduce their resistance to disease. Common side effects of chemotherapy and radiotherapy include bone marrow suppression, gastrointestinal mucosal damage, and hair loss. Among them, the gastrointestinal mucosal injury may be oral mucosal in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/18A61P1/00
CPCY02A50/30
Inventor 卢建丰吕越峰文勇袁云霞王东方
Owner 江苏奥赛康生物医药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com