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A bone repairing stent and a preparing method thereof

A technology for bone repair and gold nanorods, applied in the field of biomedical engineering, can solve the problems of poor osteogenic ability and mechanical strength, unable to simultaneously perform tumor treatment and defect repair, and low enrichment efficiency, and achieve good biocompatibility. Effects of sex, repair and treatment of bone tumor defects

Inactive Publication Date: 2019-05-03
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The enrichment efficiency of nano-photothermal materials at bone tumors is low through systemic administration, resulting in local temperatures that cannot reach the level of killing tumor cells. Even if the surface of nanomaterials is modified with tumor-targeting molecules, the enrichment rate at bone tumors Still less than 10%
[0006] The current photothermal materials are mainly nano-photothermal materials. Although nano-photothermal materials have excellent photothermal properties, these materials have poor bone formation ability and mechanical strength, and do not have the ability to repair the defects caused by bone tumor surgery. It cannot play the role of tumor treatment and defect repair at the same time; at the same time, nanomaterials are generally injected intravenously, and some nanoparticles will aggregate in normal tissues, causing certain damage to normal tissues

Method used

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  • A bone repairing stent and a preparing method thereof
  • A bone repairing stent and a preparing method thereof
  • A bone repairing stent and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A bone repair scaffold, comprising the following materials in parts by weight: 1 part of gold nanorod, 49.5 parts of β-tricalcium phosphate, and 49.5 parts of gelatin methacryloyl.

[0029] The preparation method of the bone repair bracket of this embodiment is:

[0030] (1) Preparation of gold nanorods

[0031] Weigh tetrachloroauric acid trihydrate and dissolve it in distilled water to prepare a tetrachloroauric acid solution with a concentration of 1mg / mL for later use; weigh sodium citrate and dissolve it in distilled water to prepare a citric acid solution with a concentration of 2mg / mL Sodium solution, for later use;

[0032] Measure tetrachloroauric acid solution, add distilled water to dilute it 8 times, then heat and reflux under the protection of nitrogen, then add sodium citrate solution according to the volume ratio of tetrachloroauric acid solution: sodium citrate solution = 4:1, and then react at 100°C 3h, after the reaction is over, the reaction solutio...

Embodiment 2

[0039]A bone repair scaffold, comprising the following materials in parts by weight: 5 parts of gold nanorods, 47.5 parts of β-tricalcium phosphate, and 47.5 parts of gelatin methacryloyl.

[0040] The preparation method of the bone repair scaffold in this example is the same as that in Example 1.

Embodiment 3

[0042] A bone repair bracket, comprising the following materials in parts by weight: 10 parts of gold nanorods, 45 parts of β-tricalcium phosphate, and 45 parts of gelatin methacryl.

[0043] The preparation method of the bone repair scaffold in this example is the same as that in Example 1.

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Abstract

The invention relates to a bone repairing stent and a preparing method thereof, belonging to the technical field of biomedical engineering. The stent includes gold nanorods, beta-tricalcium phosphateand gelatin methacryloyl. Through 3D printing and freeze-drying techniques, the gold nanorods having good photothermal effects are composited with the beta-tricalcium phosphate and the gelatin methacryloyl which have good osteogenic capability to prepare the bone repairing stent having good photothermal effects, and therefore, the stent has good photothermal anti-tumor capability, good biocompatibility and bone repairing and inducing capability, meeting the objectives of repairing and treating bone tumor defects.

Description

technical field [0001] The invention relates to a bone repair bracket and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] Malignant bone tumors are multiple and difficult to cure, among which metastatic bone tumors are the most common. Bone metastases occur in 65-80% of patients with advanced prostate cancer and breast cancer, and 30-40% of patients with liver cancer, lung cancer, kidney cancer, and bladder cancer. In addition, malignant bone tumors are accompanied by various complications such as bone pain, osteolysis, pathological fractures, and hypercalcemia, which bring great suffering to patients and consume a lot of medical resources. [0003] The current clinical treatment methods for bone tumors include surgical treatment, radiotherapy and chemotherapy. Surgical treatment is the main method for clinical treatment of bone tumors. Chemotherapy is a commonly used postoperative adjuvant therapy. Af...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/04A61L27/12A61L27/50A61K41/00A61P35/00B22F9/24B22F1/00B22F3/22B82Y40/00B33Y10/00B33Y80/00
Inventor 蓝咏刘玉毛宇艾淼
Owner BEOGENE BIOTECH GUANGZHOU
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