Human serum differential protein combination used in Yimusake tablet acting on erectile dysfunction, screening method and application

A technology for erectile dysfunction and screening methods, which can be applied to material testing products, measuring devices, instruments, etc., can solve the problems of unclear mechanism of action of Yimusak tablets, unclear signal transduction pathway of protein molecular mechanism, etc., and achieve the goal of treating impotence. Effect

Active Publication Date: 2019-04-16
XINJIANG MEDICAL UNIV
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Problems solved by technology

[0004] At present, the mechanism of action of Yimusak Tablets is not clear. After it acts on ED patients, the expression of proteins in the patient's body changes, the molecular mechanism of the proteins involved and the signal transduction pathways involved are not clear, so it cannot be well treated. Clinical application of Yimusak Tablets

Method used

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  • Human serum differential protein combination used in Yimusake tablet acting on erectile dysfunction, screening method and application
  • Human serum differential protein combination used in Yimusake tablet acting on erectile dysfunction, screening method and application
  • Human serum differential protein combination used in Yimusake tablet acting on erectile dysfunction, screening method and application

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Embodiment 1

[0088] Example 1 A screening method for Yimusak tablets acting on human serum differential protein combinations for penile erectile dysfunction

[0089] The research subjects were selected from May 2015 to December 2016. 60 cases of impotence patients (before treatment) diagnosed in the Andrology Department of the First Affiliated Hospital of Xinjiang Medical University and the Fourth Affiliated Hospital (before treatment) were given 15 days of oral treatment with Yimusake Tablets ( 1.0g / day), 30 cases of normal healthy people. Standards for normal people go through physical examination, electrocardiogram (ECG), chest X-ray, blood and urine routine, blood sugar, liver and kidney function tests, no organic diseases of the heart, liver, brain, lung, kidney, endocrine, immune and other major organ systems, penile erection Normal function, normal sex life, IIEF-5 index ≥ 22. The diagnostic criteria of impotence refer to the definition of the National Institutes of Health in 1993....

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Abstract

The invention provides the human serum differential protein combination used in a Yimusake tablet acting on erectile dysfunction and belongs to the screening technology field of drug target proteins.The differential protein combination comprises the 45 kinds of proteins. Based on the screening, the analysis and the verification of serum differential protein markers when the Yimusake tablet is used to treat ED patients, and the expression changes of proteins in the ED patients after the Yimusake tablet is taken are obtained, a molecular mechanism involved in the proteins and an involved signaltransduction pathway are systematically researched so as to further clarify the mechanism of a drug, guide the clinical application of the drug, and serve the secondary development of the drug. Afterthe differential protein combination is acquired, the signal path of the target protein can be researched in a targeted mode and intervention is performed on the upstream and downstream proteins so as to achieve the purpose of treating impotence.

Description

technical field [0001] The invention relates to the technical field of screening of drug action target proteins, in particular to a Yimusak tablet acting on human serum differential protein combination of penile erectile dysfunction and its screening method and application. Background technique [0002] Erectile dysfunction (ED) refers to the persistent or repeated inability to achieve or maintain a sufficient penile erection to complete a satisfactory sexual life, and also refers to the inability to continuously obtain or maintain a sufficient erection to complete a satisfactory sexual intercourse for at least 6 months . ED is a common sexual dysfunction in men, mainly affecting men over 40 years old, and its prevalence increases with age. According to research, 52% of men aged 40 to 70 suffer from different degrees of erectile dysfunction. In recent years, with the gradual increase of pressure in life, work, psychology and other aspects, the prevalence of ED has been incr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N30/88
CPCG01N30/88G01N33/6848
Inventor 阿地力江·伊明刘凤霞阿卜杜热伊木江·如则许鹏王岩斌毛吾兰·买买提依明马文静斯依提·阿木提
Owner XINJIANG MEDICAL UNIV
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