A thermosensitive polymersome and its preparation method and application
A temperature-sensitive polymer and polymer technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as difficult to control the concentration of gas molecules, unable to target tissues or cells, etc., to improve the curative effect and safety of orthodontics Sex, improve proliferation and differentiation ability, and promote the effect of remodeling
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[0052] A method for preparing thermosensitive polymersomes, comprising the steps of:
[0053] (1) Synthetic steps of thermosensitive polymer:
[0054] a. Using PEO-DDMAT as a macroinitiator, add N-isopropylacrylamide (NIPAM), coumarin monomer (CMA), and free radical initiator (AIBN) into a round bottom flask, and then add an appropriate amount of The second type of solvent, mix and remove the oxygen in the reaction system, then react at 70 ° C for 24h, and terminate the reaction by exposing to air, the resulting polymer PEO-b-P (NIPAM-stat-CMA) and tert-butyl acrylate (tBA), a free radical initiator (AIBN) and a second type of solvent are mixed to remove oxygen in the reaction system, and then react at 70° C. for 24 hours, and then terminate the reaction by exposing to air to obtain a polymer solution;
[0055] b. The obtained polymer solution was rotary evaporated, dissolved, and precipitated in n-hexane three times, and dried in vacuum at 25°C to obtain a polymer powder;
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Embodiment 1
[0069] This embodiment provides a method for preparing thermosensitive polymersomes, comprising the following steps:
[0070] (1) Synthesis steps of thermosensitive polymer PEO-b-P(NIPAM-stat-CMA)-b-PAA:
[0071] a. Using 0.68g (0.30mmol) PEO-DDMAT as a macroinitiator, 2.71g (24.00mmol) N-isopropylacrylamide (NIPAM), 1.00g (3.3mmol) coumarin monomer (CMA) , 7.38mg (0.045mmol) free radical initiator (AIBN) was added in the 25mL round bottom flask, then added 3mL of dioxane, until all the reactants were dissolved, blowing argon for 15 minutes by bubbling to remove the reaction Oxygen in the system (forming an oxygen-free environment), carry out reversible addition-fragmentation chain transfer polymerization (RAFT), the reaction temperature is 50 ° C, the reaction time is 48h, the reaction is terminated by exposure to air, and the obtained polymer PEO-b-P (NIPAM-stat-CMA) is mixed with 0.46g (3.6mmol) tert-butyl acrylate (tBA) 7.38mg (0.045mmol) free radical initiator (AIBN) and...
Embodiment 2
[0080] This embodiment provides a method for preparing thermosensitive polymersomes, comprising the following steps:
[0081] (1) Synthesis steps of thermosensitive polymer PEO-b-P(NIPAM-stat-CMA)-b-PAA:
[0082] a. With 0.68g (0.30mmol) PEO-DDMAT as a macroinitiator, 3.39g (30.00mmol) N-isopropylacrylamide (NIPAM), 1.21g (4.0mmol) coumarin monomer (CMA) , 7.38mg (0.045mmol) of free radical initiator (AIBN) was added to a 25mL round bottom flask, and then 5mL of dimethylformamide was added, and until all the reactants were dissolved, argon gas was blown for 15 minutes by bubbling to remove Oxygen in the reaction system (form an oxygen-free environment), carry out reversible addition-fragmentation chain transfer polymerization (RAFT), the reaction temperature is 60 ° C, the reaction time is 36h, the reaction is terminated by exposure to air, and the obtained polymer PEO- b-P (NIPAM-stat-CMA) is mixed with 0.51g (4.0mmol) tert-butyl acrylate (tBA), 7.38mg (0.045mmol) free radic...
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