Application of traditional Chinese medicine composition for treating depression in regulating immune inflammatory reaction

Abstract

The present invention relates to the technical field of medicine and particularly relates to an application of a traditional Chinese medicine composition for treating depression in regulating an immune inflammatory reaction and an intervention mechanism and the application of the traditional Chinese medicine composition for treating the depression, and the traditional Chinese medicine compositioncomprises radix curcumae, spina date seeds, American ginseng and fructus schizandrae. The traditional Chinese medicine composition significantly reverses up-regulated expression levels of TLR4 and MyD88 proteins in hippocampus induced by chronic restraint stress under reversal functions of interventions on chronic restraint stress-induced rat weight loss, decreased sweet water preference index, decreased horizontal motor scores and vertical motor scores, etc., and at the same time widely regulates immunoinflammatory activation mediated by a pattern recognition receptor TLR4 signaling pathway.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a traditional Chinese medicine composition for treating depression in regulating immune inflammatory response. Background technique [0002] Depression is an affective mental disorder that seriously affects people's quality of life, psychological and social functions. It is a common disease in psychiatry. It includes a variety of mental symptoms and physical symptoms. In addition to mental symptoms such as depression, loss of interest, slow thinking, and low self-evaluation, it also includes physical discomfort such as fatigue, insomnia, loss of appetite, loss of libido, headache, dizziness, thirst, throat discomfort, chest tightness, palpitation, Stomach pain, abdominal distension, etc. In severe cases, there may be a sense of self-intimidation and even suicidal tendencies. With the progress of society and economic development, the intensification of social ...

AI Technical Summary

Problems solved by technology

In the treatment of depression, the antidepressants and palliative treatments currently used cannot meet the needs of practice, and their application is limited

On the one hand, the ingredients used in the existing antidepressants are complex, which are prone to rejection reactions with the human body, have serious side effects, and have a long clinical onset time; on the other hand, the existing antidepressants have no curative effect on some depressed patients effect, and many depressed patients relapse after stopping antidepressants

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