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Processing method of fructus gardeniae and application of processed fructus gardeniae in preparation of antidepressants

A technology of gardenia and medicinal materials, which is applied in the processing method of gardenia and its antidepressant application field, can solve the problems of not establishing modern objective and scientific quality evaluation standards, achieve the alleviation of gardenia toxicity, and the processing conditions are reasonable and comprehensive quality effect

Inactive Publication Date: 2019-04-12
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the quality control of Jiangzhizi decoction pieces is mostly based on the traditional appearance experience judgment method, and no modern objective and scientific quality evaluation standards have been established.

Method used

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  • Processing method of fructus gardeniae and application of processed fructus gardeniae in preparation of antidepressants
  • Processing method of fructus gardeniae and application of processed fructus gardeniae in preparation of antidepressants
  • Processing method of fructus gardeniae and application of processed fructus gardeniae in preparation of antidepressants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 10kg of mature gardenia after frost, remove impurities, put it in a microwave generator, control the microwave power to 600w, heat for 40s, take it out, crush it, add 1.25kg of ginger juice, mix well, moisten it for 1.5 hours, and dry it in hot air In the box, control the temperature at 140°C, heat for 12 minutes, and bake until the surface of the gardenia is brownish brown. Take it out, spread it out, let it cool, and sieve off the debris. The contents of geniposide and saffron Ⅰ were determined to be 42.46mg / g and 4.07mg / g respectively by using the above-mentioned chromatographic conditions.

Embodiment 2

[0045] Take 10kg of mature gardenia after frost, remove impurities, put it in a microwave generator, control the microwave power to 800w, heat for 30s, take it out, crush it, add 1.0kg of ginger juice, mix well, moisten it for 1.5 hours, and dry it with hot air In the box, control the temperature at 100°C, heat for 8 minutes, bake until the surface of the gardenia is burnt yellow, take it out, spread it out, let it cool, sieve off the debris, and get it. The contents of geniposide and saffron Ⅰ were determined to be 40.07mg / g and 3.93mg / g respectively by using the above-mentioned chromatographic conditions.

Embodiment 3

[0047] Take 10kg of mature gardenia after frost, remove impurities, put it in a microwave generator, control the microwave power to 300w, heat for 60s, take it out, crush it, add 1.25kg of ginger juice, mix well, moisten it for 1.0 hours, and dry it in hot air In the box, control the temperature at 100°C, heat for 12 minutes, bake until the surface of the gardenia is burnt yellow, take it out, spread it out, let it cool, sieve off the debris, and get it. The contents of geniposide and saffron Ⅰ were determined to be 41.07mg / g and 3.96mg / g respectively by using the above chromatographic conditions.

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Abstract

The invention discloses a processing method of fructus gardeniae and antidepressant application of processed fructus gardeniae. The processing method includes the following steps: (1) taking fructus gardenia raw medicinal materials, and removing non-medicinal parts such as impurities, fruit stalks and branches; (2) taking clean fructus gardeniae to be put in a microwave generator, controlling themicrowave power to be 300-800w, performing heating for 30-60s, taking out the heated fructus gardeniae and performing crushing; (3) mixing crushed fructus gardeniae and ginger juice evenly to be put in a container with a cover, and performing covered moistening for 1-2 hours; and (4) taking the fructus gardeniae obtained in the step 3 to be put in a hot air drying box, and performing drying untilthe color of the fructus gardenia deepens to be burnt yellow or burnt yellowish-brown to obtain the processed fructus gardenia. The ginger fructus gardenia obtained by the processing method provided by the invention can effectively alleviate the toxic and side effects of the fructus gardenia, and maintain the content of gardenoside and saffron pigments. The processing method is simple. The pharmacological experiment proves that the obtained ginger fructus gardenia can significantly improve the depressive behavior of chronic stress-induced depression model rats.

Description

technical field [0001] The invention belongs to the technical field of processing traditional Chinese medicines, and in particular relates to a processing method of gardenia jasmine and its antidepressant application. technical background [0002] Gardenia is the dry ripe fruit of Gardenia jasminoides Ellis, a Rubiaceae plant. Nature and flavor are bitter, cold. Guixin, Lung and Sanjiao meridians have the effects of purging fire and relieving restlessness, clearing heat and promoting dampness, cooling blood and detoxifying. The processing methods of gardenia have been rich in the past dynasties, which are mainly divided into several categories such as net preparation, supplementary materials and no supplementary materials. Today, only several processing methods such as net preparation, fried yellow, fried coke, fried charcoal, wine and ginger are used. . Gardenia was first recorded in "Shen Nong's Materia Medica", but there is no record of its processing. The earliest pr...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P25/24
CPCA61K36/744A61K2236/13A61K2236/15A61K2236/17A61P25/24
Inventor 吴浩然黄晓燕孙广达蒋睿智单鑫陶伟伟
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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