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A kind of tropicamide ophthalmic composition and its preparation method and application

A technology for tropicamide eye and picamide eye, which is applied in the directions of drug combinations, medical preparations containing active ingredients, and medical preparations without active ingredients, etc. Problems such as the inability to relieve irritation symptoms, achieve good ocular surface lubrication, good pupil dilation, and improve eye irritation

Active Publication Date: 2021-04-20
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above-mentioned prior art effectively avoids the toxic side effects and potential risks caused by antibacterial agents to the eyes, the use of tropicamide can lead to a slight increase in intraocular pressure, which in turn causes eye irritation in patients but cannot be relieved

Method used

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  • A kind of tropicamide ophthalmic composition and its preparation method and application
  • A kind of tropicamide ophthalmic composition and its preparation method and application
  • A kind of tropicamide ophthalmic composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prescription of tropicamide ophthalmic composition (based on the total weight of tropicamide ophthalmic composition):

[0041]

[0042] The weight ratio of tropicamide to polyvinyl alcohol in the tropicamide ophthalmic composition is 0.5:1.

[0043] The preparation method of tropicamide ophthalmic composition:

[0044] Inject part of the required amount of water for injection at a temperature of 100°C into the batching tank, weigh the required amount of tropicamide, polyvinyl alcohol, sodium dihydrogen phosphate, and disodium hydrogen phosphate and add them to the water for injection in sequence, each time The ingredients are all stirred to make the materials fully dissolved, and then water for injection is added to the full amount to prepare the tropicamide ophthalmic composition.

Embodiment 2

[0046] Prescription of tropicamide ophthalmic composition (based on the total weight of tropicamide ophthalmic composition):

[0047]

[0048]

[0049] The weight ratio of tropicamide to polyvinyl alcohol in the tropicamide ophthalmic composition is 1:1.

[0050] The preparation method of tropicamide ophthalmic composition:

[0051] Inject part of the required amount of water for injection at a temperature of 100°C into the batching tank, weigh the required amount of tropicamide, polyvinyl alcohol, boric acid, and borax and add them to the water for injection in sequence, and stir each time to make the material fully Dissolve, and then add water for injection to the full amount to prepare tropicamide ophthalmic composition.

Embodiment 3

[0053] Prescription of tropicamide ophthalmic composition (based on the total weight of tropicamide ophthalmic composition):

[0054] Tropicamide 0.5wt%;

[0055] Polyvinyl alcohol 0.05wt%;

[0056] Sodium acetate 0.27% by weight; and

[0057] The balance is water for injection.

[0058] The weight ratio of tropicamide to polyvinyl alcohol in the tropicamide ophthalmic composition is 10:1.

[0059] The preparation method of tropicamide ophthalmic composition:

[0060]Inject part of the required amount of water for injection at a temperature of 100°C into the batching tank, weigh the required amount of tropicamide, polyvinyl alcohol, and sodium acetate into the water for injection in sequence, and stir each time to fully dissolve the material , and then add water for injection to the full amount to prepare the tropicamide ophthalmic composition.

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Abstract

The invention discloses a tropicamide ophthalmic composition and relates to the field of pharmaceutical preparations. The tropicamide ophthalmic composition comprises tropicamide, polyvinyl alcohol, a pH regulator and water for injection. The invention also discloses a preparation method of the tropicamide ophthalmic composition, which comprises mixing tropicamide, polyvinyl alcohol, a pH regulator and water for injection to obtain the tropicamide ophthalmic composition. In addition, the present invention further discloses the application of a tropicamide ophthalmic composition in eye drops. The tropicamide ophthalmic composition provided by the invention has good mydriasis effect, can obviously improve eye irritation, and makes patients have better compliance.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a tropicamide ophthalmic composition and a preparation method and application thereof. Background technique [0002] Tropicamide eye drops are used to dilate mydriasis and check fundus and diopter. Most of the tropicamide eye drops on the market contain antibacterial agents and are packaged in multiple doses for repeated use. Once the preparation is opened, it is easy to be contaminated by tears and microbes in the air during use and storage, thereby causing safety hazards. In order to prevent ophthalmic preparations from being contaminated by microorganisms during repeated use after opening, bacteriostatic agents are added to ophthalmic preparations, and bacteriostatic agents are used in almost all eye drop prescriptions in the "Chinese Hospital Preparation Standards" . Antibacterial agents, also known as preservatives or preservatives, refer to chemical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/4409A61K47/32A61P27/02
CPCA61K9/0048A61K9/08A61K31/4409A61K47/32A61P27/02
Inventor 王超付欢尹传忠万利鹏延静梁琴
Owner 湖北远大天天明制药有限公司
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