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Tropicamide ophthalmic composition, and preparing method and application thereof

A technology for tropicamide eye and picamide eye, applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of mildly elevated intraocular pressure and eye problems Irritation symptoms can not be alleviated and other problems, to achieve the effect of good ocular surface lubrication, good mydriatic effect, and simple preparation method

Active Publication Date: 2019-04-02
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above-mentioned prior art effectively avoids the toxic side effects and potential risks caused by antibacterial agents to the eyes, the use of tropicamide can lead to a slight increase in intraocular pressure, which in turn causes eye irritation in patients but cannot be relieved

Method used

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  • Tropicamide ophthalmic composition, and preparing method and application thereof
  • Tropicamide ophthalmic composition, and preparing method and application thereof
  • Tropicamide ophthalmic composition, and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The prescription of the tropicamide ophthalmic composition (based on the total weight of the tropicamide ophthalmic composition):

[0041]

[0042] The weight ratio of tropicamide to polyvinyl alcohol in the tropicamide ophthalmic composition is 0.5:1.

[0043] Preparation method of tropicamide ophthalmic composition:

[0044] Pour part of the required amount of water for injection with a temperature of 100°C into the batching tank, weigh the required amount of tropecaramide, polyvinyl alcohol, sodium dihydrogen phosphate, and disodium hydrogen phosphate into the water for injection in turn, each time All the materials are stirred to fully dissolve the materials, and then water for injection is added to the full amount to prepare the tropicamide ophthalmic composition.

Embodiment 2

[0046] The prescription of the tropicamide ophthalmic composition (based on the total weight of the tropicamide ophthalmic composition):

[0047]

[0048]

[0049] The weight ratio of tropicamide to polyvinyl alcohol in the tropicamide ophthalmic composition is 1:1.

[0050] Preparation method of tropicamide ophthalmic composition:

[0051] Pour part of the required amount of water for injection with a temperature of 100°C into the batching tank, weigh the required amount of tropicamide, polyvinyl alcohol, boric acid, and borax into the water for injection, and stir each time to make the material sufficient Dissolve, and then add water for injection to the full amount to prepare the tropicamide ophthalmic composition.

Embodiment 3

[0053] The prescription of the tropicamide ophthalmic composition (based on the total weight of the tropicamide ophthalmic composition):

[0054] Toppicamide 0.5wt%;

[0055] Polyvinyl alcohol 0.05wt%;

[0056] Sodium acetate 0.27wt%; and

[0057] The balance is water for injection.

[0058] The weight ratio of tropicamide to polyvinyl alcohol in the tropicamide ophthalmic composition is 10:1.

[0059] Preparation method of tropicamide ophthalmic composition:

[0060] Pour part of the required amount of water for injection with a temperature of 100°C into the batching tank, weigh the required amount of tropicamide, polyvinyl alcohol, and sodium acetate into the water for injection in sequence, and stir each time to fully dissolve the material , And then add water for injection to the full amount to prepare the tropicamide ophthalmic composition.

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Abstract

The invention discloses a tropicamide ophthalmic composition, and relates to the field of pharmaceutical preparations. The tropicamide ophthalmic composition comprises tropicamide, polyvinyl alcohol,a pH regulator and water for injection. The invention also discloses a preparing method of the tropicamide ophthalmic composition, wherein the preparing method comprises the steps of mixing tropicamide, polyvinyl alcohol, the pH regulator and water for injection to obtain the tropicamide ophthalmic composition. In addition, the invention further discloses an application of the tropicamide ophthalmic composition in eye drops. The tropicamide ophthalmic composition provided by the invention has good mydriasis effect, can obviously improve eye irritation and makes patients have good compliance.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a toppicamide ophthalmic composition and a preparation method and application thereof. Background technique [0002] Toppicamide eye drops are used to dilate pupils and check the fundus and refractive power. Most of the toppicamide eye drops on the market contain antibacterial agents, which are packaged in multiple doses and used repeatedly. Once the preparation is opened, it is easy to be contaminated by tears and microorganisms in the air during use and storage, thereby causing potential safety hazards. In order to prevent ophthalmic preparations from being contaminated by microorganisms during repeated use after opening, bacteriostatic agents are added to ophthalmic preparations. Almost all eye drop prescriptions in the "Chinese Hospital Preparation Specifications" use bacteriostatic agents . Bacteriostatic agents, also known as preservatives or preservativ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4409A61K47/32A61P27/02
CPCA61K9/0048A61K9/08A61K31/4409A61K47/32A61P27/02
Inventor 王超付欢尹传忠万利鹏延静梁琴
Owner 湖北远大天天明制药有限公司
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