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Medicine for reducing hormone resistance of patients with steroid-resistant nephrotic syndrome

A technology for nephrotic syndrome and hormone resistance, which can be applied to drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as affecting the quality of drug preparation, low drug cure rate, and reducing tablet hardness, so as to improve the quality of drug preparation, improve the Improve the cure rate and reduce the effect of recurrence

Pending Publication Date: 2019-03-29
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In summary, the existing problems in the prior art are: the cure rate of existing medicines for reducing hormone resistance in patients with steroid-resistant nephrotic syndrome is low; the purity of ethanol used in the preparation process is low; at the same time, the magnesium stearate used Hydrophobic, usually due to over-lubricating effect to block drug dissolution and reduce tablet hardness; affect the quality of drug preparation

Method used

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  • Medicine for reducing hormone resistance of patients with steroid-resistant nephrotic syndrome

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preparation example Construction

[0035] Such as figure 1 As shown, the method for preparing medicines for reducing steroid-resistant nephrotic syndrome patients' resistance to steroids provided by the embodiments of the present invention specifically includes the following steps:

[0036] S101: Combine plantain heart, turtle shell, blood vine, gerbera, corydalis, horse chestnut, raw malt, milletus, medlar, blue cloth, Codonopsis pilosula, Rehmannia glutinosa, Gorgon fruit, Sangji, Morinda officinalis, Cornus officinalis, Wujiapi and Nansha ginseng were pulverized respectively, passed through a 50-mesh sieve, and sent to a mixer in parts by weight to stir and mix evenly to obtain a mixture;

[0037] S102: Add water and decoct the mixed medicine for 4 times. After the first boiling, decoct with high heat for 20 minutes; after the second boiling, decoct with low heat for 40 minutes; ;

[0038] S103: Combine the decoction, prepare the first dry powder and the second dry powder, and set aside;

[0039] S104: Pr...

Embodiment 1

[0095] The medicine for reducing the hormone resistance of patients with steroid-resistant nephrotic syndrome provided by the embodiments of the present invention consists of 31 parts by mass of plantain heart, 13 parts of turtle shell, 6 parts of sage vine, 9 parts of gerbera, and 10 parts of corydalis , 12 parts of Aescinus, 9 parts of raw malt, 7 parts of Caulis Spatholobus, 30 parts of medlar, 6 parts of blue cloth, 14 parts of Codonopsis, 24 parts of Rehmannia glutinosa, 29 parts of Gorgon fruit, 30 parts of Sangjisheng, Morinda officinalis 30 parts, 18 parts of Cornus officinalis, 13 parts of Wujiapi, 16 parts of Nansha ginseng, 1 part of magnesium stearate and 16 parts of ethanol.

Embodiment 2

[0097] The medicine for reducing the steroid resistance of patients with steroid-resistant nephrotic syndrome provided by the embodiments of the present invention consists of 35 parts of plantain heart, 15 parts of turtle shell, 8 parts of Rhizoma chinensis, 11 parts of gerbera, and 12 parts of Corydalis Corydalis in terms of mass parts , 16 parts of Aescin, 13 parts of raw malt, 11 parts of Caulis Spatholobus, 50 parts of medlar, 10 parts of blue cloth, 20 parts of Codonopsis, 30 parts of Rehmannia glutinosa, 35 parts of Gorgon fruit, 32 parts of Sangjisheng, Morinda officinalis 34 parts, 20 parts of dogwood, 15 parts of Wujiapi, 20 parts of Nansha ginseng, 2 parts of magnesium stearate and 20 parts of ethanol.

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Abstract

The invention belongs to the technical field of medicine preparation, and discloses a medicine for reducing hormone resistance of patients with steroid-resistant nephrotic syndrome. The medicine preparation can be used for treating nephrotic syndrome, can reduce side effect of hormone, reduces rebound phenomenon after hormone is used, improves the sensitivity of nephrotic syndrome hormone, prevents infection, reduces recurrence, and improves the cure rate of nephrotic syndrome patients. Meanwhile, compared with common magnesium stearate, the magnesium stearate prepared by the method has the advantages of quite excellent fluidity, viscosity resistance and flow aiding property. The specific volume value of the magnesium stearate prepared by the invention is lower than 1.5g / ml, and the angleof repose is 30 degrees. The magnesium stearate is used in tablets together with common magnesium stearate in the same proportion so as to effectively improve the hardness of the tablets by about 30 percent, to fully improve the dissolution of the medicine, and to improve the quality of the prepared medicine for reducing the hormone resistance of patients with steroid-resistant nephrotic syndrome.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a medicine for reducing hormone resistance of patients with steroid-resistant nephrotic syndrome. Background technique [0002] Nephrotic syndrome (NS) can be caused by a variety of etiologies. The increase in the permeability of the glomerular basement membrane is manifested as a group of clinical syndromes of massive proteinuria, hypoalbuminemia, high edema, and hyperlipidemia. The most basic features of NS are massive proteinuria, hypoproteinemia, (high) edema and hyperlipidemia, the so-called "three highs and one low", and a group of clinical syndromes characterized by other metabolic disorders. Massive proteinuria is the main clinical manifestation of NS patients, and it is also the most basic pathophysiological mechanism of nephrotic syndrome. Massive proteinuria refers to the excretion of urinary protein in adults > 3.5g / d. Under normal physio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61K9/48A61K47/36A61K47/12A61P13/12A61K35/586
CPCA61K36/8998A61P13/12A61K9/1652A61K9/4858A61K35/586A61K36/185A61K36/25A61K36/254A61K36/28A61K36/342A61K36/344A61K36/40A61K36/486A61K36/57A61K36/62A61K36/66A61K36/73A61K36/746A61K36/804A61K36/815A61K36/88A61K2236/39A61K2236/333A61K2236/331A61K2300/00
Inventor 梁艳唐琳苟蓉郭园园王刘伟于露王玉林郭艳红
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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